Human Gene SDS (ENST00000257549.9) from GENCODE V44
Description: Homo sapiens serine dehydratase (SDS), mRNA. (from RefSeq NM_006843) RefSeq Summary (NM_006843): This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000257549.9 Gencode Gene: ENSG00000135094.11 Transcript (Including UTRs) Position: hg38 chr12:113,392,445-113,403,887 Size: 11,443 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr12:113,392,941-113,399,708 Size: 6,768 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20132
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006094 gluconeogenesis GO:0006520 cellular amino acid metabolic process GO:0006565 L-serine catabolic process GO:0019518 L-threonine catabolic process to glycine GO:0042866 pyruvate biosynthetic process