Human Gene PXN (ENST00000323871.9) from GENCODE V44
Description: paxillin (from HGNC PXN)
RefSeq Summary (NM_001080855): This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000323871.9
Gencode Gene: ENSG00000089159.17
Transcript (Including UTRs)
Position: hg38 chr12:120,210,451-120,265,718 Size: 55,268 Total Exon Count: 14 Strand: -
Coding Region
Position: hg38 chr12:120,216,712-120,265,629 Size: 48,918 Coding Exon Count: 8
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BC006840 - Homo sapiens cDNA clone IMAGE:3450608.BC015217 - Homo sapiens paxillin, mRNA (cDNA clone IMAGE:3852361).BC010498 - Homo sapiens paxillin, mRNA (cDNA clone IMAGE:3448445).BC003647 - Homo sapiens paxillin, mRNA (cDNA clone IMAGE:3534159), partial cds.BX648777 - Homo sapiens mRNA; cDNA DKFZp686N21130 (from clone DKFZp686N21130).AK128712 - Homo sapiens cDNA FLJ46879 fis, clone UTERU3015011, highly similar to Paxillin.AK122964 - Homo sapiens cDNA FLJ16691 fis, clone TRACH3000692, highly similar to Paxillin.AB209034 - Homo sapiens mRNA for Paxillin variant protein.U14588 - Human paxillin mRNA, complete cds.JD215434 - Sequence 196458 from Patent EP1572962.JD365885 - Sequence 346909 from Patent EP1572962.JD104566 - Sequence 85590 from Patent EP1572962.JD069204 - Sequence 50228 from Patent EP1572962.JD285723 - Sequence 266747 from Patent EP1572962.JD166363 - Sequence 147387 from Patent EP1572962.JD215852 - Sequence 196876 from Patent EP1572962.JD277432 - Sequence 258456 from Patent EP1572962.JD271726 - Sequence 252750 from Patent EP1572962.JD259985 - Sequence 241009 from Patent EP1572962.JD201058 - Sequence 182082 from Patent EP1572962.JD300981 - Sequence 282005 from Patent EP1572962.JD427488 - Sequence 408512 from Patent EP1572962.JD245307 - Sequence 226331 from Patent EP1572962.JD538994 - Sequence 520018 from Patent EP1572962.JD502522 - Sequence 483546 from Patent EP1572962.JD428726 - Sequence 409750 from Patent EP1572962.BC136787 - Homo sapiens paxillin, mRNA (cDNA clone MGC:168400 IMAGE:9020777), complete cds.BC136794 - Homo sapiens paxillin, mRNA (cDNA clone MGC:168407 IMAGE:9020784), complete cds.BC144410 - Homo sapiens paxillin, mRNA (cDNA clone MGC:177948 IMAGE:9052931), complete cds.AK298057 - Homo sapiens cDNA FLJ57756 complete cds, highly similar to Paxillin.JD243075 - Sequence 224099 from Patent EP1572962.JD253774 - Sequence 234798 from Patent EP1572962.JD477457 - Sequence 458481 from Patent EP1572962.JD271731 - Sequence 252755 from Patent EP1572962.JD379547 - Sequence 360571 from Patent EP1572962.JD516778 - Sequence 497802 from Patent EP1572962.JD260001 - Sequence 241025 from Patent EP1572962.JD252972 - Sequence 233996 from Patent EP1572962.JD109115 - Sequence 90139 from Patent EP1572962.AK299486 - Homo sapiens cDNA FLJ57182 complete cds, highly similar to Paxillin.JD456730 - Sequence 437754 from Patent EP1572962.JD355054 - Sequence 336078 from Patent EP1572962.JD321318 - Sequence 302342 from Patent EP1572962.JD261564 - Sequence 242588 from Patent EP1572962.JD412431 - Sequence 393455 from Patent EP1572962.HM005447 - Homo sapiens clone HTL-T-134 testicular tissue protein Li 134 mRNA, complete cds.JD424432 - Sequence 405456 from Patent EP1572962.D86862 - Homo sapiens mRNA for paxillin beta, complete cds.D86863 - Homo sapiens mRNA for paxillin gamma, complete cds.AK314204 - Homo sapiens cDNA, FLJ94932, Homo sapiens paxillin (PXN), mRNA.KJ897432 - Synthetic construct Homo sapiens clone ccsbBroadEn_06826 PXN gene, encodes complete protein.AB590484 - Synthetic construct DNA, clone: pFN21AE2012, Homo sapiens PXN gene for paxillin, without stop codon, in Flexi system.MP014884 - Sequence 87 from Patent WO2019016252.AK026695 - Homo sapiens cDNA: FLJ23042 fis, clone LNG02323.BC052611 - Homo sapiens paxillin, mRNA (cDNA clone IMAGE:6252827), complete cds.JD099648 - Sequence 80672 from Patent EP1572962.JD408003 - Sequence 389027 from Patent EP1572962.JD371137 - Sequence 352161 from Patent EP1572962.JD451448 - Sequence 432472 from Patent EP1572962.JD095100 - Sequence 76124 from Patent EP1572962.JD335741 - Sequence 316765 from Patent EP1572962.FW365445 - COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04062 - Chemokine signaling pathwayhsa04370 - VEGF signaling pathwayhsa04510 - Focal adhesionhsa04670 - Leukocyte transendothelial migrationhsa04810 - Regulation of actin cytoskeletonhsa05100 - Bacterial invasion of epithelial cells
Other Names for This Gene
Alternate Gene Symbols: A0A1B0GU60, AB209034, ENST00000323871.1, ENST00000323871.2, ENST00000323871.3, ENST00000323871.4, ENST00000323871.5, ENST00000323871.6, ENST00000323871.7, ENST00000323871.8, uc001txz.1, uc001txz.2, uc001txz.3, uc001txz.4, uc001txz.5UCSC ID: ENST00000323871.9RefSeq Accession: NM_001080855
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.