Human Gene BRI3BP (ENST00000341446.9) from GENCODE V44
  Description: Homo sapiens BRI3 binding protein (BRI3BP), mRNA. (from RefSeq NM_080626)
Gencode Transcript: ENST00000341446.9
Gencode Gene: ENSG00000184992.13
Transcript (Including UTRs)
   Position: hg38 chr12:124,993,645-125,031,231 Size: 37,587 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr12:124,993,791-125,025,430 Size: 31,640 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:124,993,645-125,031,231)mRNA (may differ from genome)Protein (251 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BRI3B_HUMAN
DESCRIPTION: RecName: Full=BRI3-binding protein; Short=I3-binding protein; AltName: Full=Cervical cancer 1 proto-oncogene-binding protein KG19; AltName: Full=HCCRBP-1;
FUNCTION: Involved in tumorigenesis and may function by stabilizing p53/TP53.
SUBUNIT: Interacts with LETMD1.
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.
SEQUENCE CAUTION: Sequence=AAL33003.2; Type=Frameshift; Positions=43, 47, 59;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.60 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 150.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.50146-0.531 Picture PostScript Text
3' UTR -2059.205801-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8WY22
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF384028 - JP 2014500723-A/191531: Polycomb-Associated Non-Coding RNAs.
MA619605 - JP 2018138019-A/191531: Polycomb-Associated Non-Coding RNAs.
JD186850 - Sequence 167874 from Patent EP1572962.
BC034525 - Homo sapiens BRI3 binding protein, mRNA (cDNA clone MGC:24938 IMAGE:4778946), complete cds.
AF284094 - Homo sapiens I3 binding protein (BRI3BP) mRNA, complete cds.
AF283671 - Homo sapiens cervical cancer 1 proto-oncogene-binding protein KG19 (KG19) mRNA, complete cds.
AF441865 - Homo sapiens cervical cancer oncogene binding protein mRNA, complete cds.
AK055703 - Homo sapiens cDNA FLJ31141 fis, clone IMR322001245.
JD285753 - Sequence 266777 from Patent EP1572962.
JD462131 - Sequence 443155 from Patent EP1572962.
JD338388 - Sequence 319412 from Patent EP1572962.
JD053156 - Sequence 34180 from Patent EP1572962.
JD041027 - Sequence 22051 from Patent EP1572962.
JD296513 - Sequence 277537 from Patent EP1572962.
JD410006 - Sequence 391030 from Patent EP1572962.
AK025766 - Homo sapiens cDNA: FLJ22113 fis, clone HEP18418.
JD202532 - Sequence 183556 from Patent EP1572962.
JD119017 - Sequence 100041 from Patent EP1572962.
JD454124 - Sequence 435148 from Patent EP1572962.
JD376129 - Sequence 357153 from Patent EP1572962.
JD222955 - Sequence 203979 from Patent EP1572962.
JD497928 - Sequence 478952 from Patent EP1572962.
JD537304 - Sequence 518328 from Patent EP1572962.
JD112108 - Sequence 93132 from Patent EP1572962.
JD112109 - Sequence 93133 from Patent EP1572962.
JD258426 - Sequence 239450 from Patent EP1572962.
JD411902 - Sequence 392926 from Patent EP1572962.
JD563251 - Sequence 544275 from Patent EP1572962.
JD286068 - Sequence 267092 from Patent EP1572962.
JD083303 - Sequence 64327 from Patent EP1572962.
DL492429 - Novel nucleic acids.
DL490908 - Novel nucleic acids.
JD023636 - Sequence 4660 from Patent EP1572962.
JD029315 - Sequence 10339 from Patent EP1572962.
JD032594 - Sequence 13618 from Patent EP1572962.
JD327246 - Sequence 308270 from Patent EP1572962.
JD294225 - Sequence 275249 from Patent EP1572962.
JD432582 - Sequence 413606 from Patent EP1572962.
JD294224 - Sequence 275248 from Patent EP1572962.
JD472562 - Sequence 453586 from Patent EP1572962.
JD065944 - Sequence 46968 from Patent EP1572962.
JD522498 - Sequence 503522 from Patent EP1572962.
JD069856 - Sequence 50880 from Patent EP1572962.
LF359742 - JP 2014500723-A/167245: Polycomb-Associated Non-Coding RNAs.
MA595319 - JP 2018138019-A/167245: Polycomb-Associated Non-Coding RNAs.
MP014883 - Sequence 86 from Patent WO2019016252.

-  Other Names for This Gene
  Alternate Gene Symbols: BRI3B_HUMAN, ENST00000341446.1, ENST00000341446.2, ENST00000341446.3, ENST00000341446.4, ENST00000341446.5, ENST00000341446.6, ENST00000341446.7, ENST00000341446.8, KG19, NM_080626, Q8WY22, Q8WY23, uc001uha.1, uc001uha.2, uc001uha.3
UCSC ID: ENST00000341446.9
RefSeq Accession: NM_080626
Protein: Q8WY22 (aka BRI3B_HUMAN)
CCDS: CCDS9262.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.