Human Gene GTF3A (ENST00000470606.5) from GENCODE V44
  Description: general transcription factor IIIA (from HGNC GTF3A)
RefSeq Summary (NM_002097): The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000470606.5
Gencode Gene: ENSG00000122034.17
Transcript (Including UTRs)
   Position: hg38 chr13:27,425,411-27,435,688 Size: 10,278 Total Exon Count: 9 Strand: +


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:27,425,411-27,435,688)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGencodeHGNCLynxMalacards
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GTF3A
Diseases sorted by gene-association score: thrombasthenia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.36 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1005.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC143711 - Homo sapiens cDNA clone IMAGE:9052225.
D32257 - Homo sapiens GTF3A mRNA for Xenopus transcription factor IIIA homologue, complete cds.
E10962 - cDNA's encoding hTFIIIA protein.
AB590496 - Synthetic construct DNA, clone: pFN21AE1232, Homo sapiens GTF3A gene for general transcription factor IIIA, without stop codon, in Flexi system.
U14134 - Human transcription factor IIIA (HTFIIIA) mRNA, partial cds.
U20272 - Human DNA/RNA-binding protein mRNA, partial cds.
AK057993 - Homo sapiens cDNA FLJ25264 fis, clone STM05057, highly similar to TRANSCRIPTION FACTOR IIIA.
JD034924 - Sequence 15948 from Patent EP1572962.
CU692321 - Synthetic construct Homo sapiens gateway clone IMAGE:100021331 3' read MTIF3 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: AK057993, ENST00000470606.1, ENST00000470606.2, ENST00000470606.3, ENST00000470606.4, uc001urg.1, uc001urg.2, uc001urg.3
UCSC ID: ENST00000470606.5
RefSeq Accession: NM_002097

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.