Human Gene DCLK1 (ENST00000615680.5) from GENCODE V44
Description: Homo sapiens doublecortin like kinase 1 (DCLK1), transcript variant 2, mRNA. (from RefSeq NM_001195415) RefSeq Summary (NM_001195415): This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]. Gencode Transcript: ENST00000615680.5 Gencode Gene: ENSG00000133083.15 Transcript (Including UTRs) Position: hg38 chr13:35,771,353-35,855,667 Size: 84,315 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr13:35,774,642-35,855,528 Size: 80,887 Coding Exon Count: 14
ID:DCLK1_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase DCLK1; EC=2.7.11.1; AltName: Full=Doublecortin domain-containing protein 3A; AltName: Full=Doublecortin-like and CAM kinase-like 1; AltName: Full=Doublecortin-like kinase 1; FUNCTION: Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. TISSUE SPECIFICITY: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. INDUCTION: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. SIMILARITY: Contains 2 doublecortin domains. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAA20824.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15075
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
