Human Gene CKAP2 (ENST00000258607.10) from GENCODE V44
Description: Homo sapiens cytoskeleton associated protein 2 (CKAP2), transcript variant 1, mRNA. (from RefSeq NM_018204) RefSeq Summary (NM_018204): This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]. Gencode Transcript: ENST00000258607.10 Gencode Gene: ENSG00000136108.15 Transcript (Including UTRs) Position: hg38 chr13:52,455,478-52,476,627 Size: 21,150 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr13:52,455,557-52,475,141 Size: 19,585 Coding Exon Count: 9
ID:CKAP2_HUMAN DESCRIPTION: RecName: Full=Cytoskeleton-associated protein 2; AltName: Full=CTCL tumor antigen se20-10; AltName: Full=Tumor- and microtubule-associated protein; FUNCTION: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). SUBUNIT: Associates with alpha- and beta-tubulins (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules. TISSUE SPECIFICITY: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. DEVELOPMENTAL STAGE: Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C). INDUCTION: Up-regulated in primary human gastric cancers. SIMILARITY: Belongs to the CKAP2 family. SEQUENCE CAUTION: Sequence=AAG33675.1; Type=Frameshift; Positions=607; Sequence=AAH10901.1; Type=Erroneous initiation; Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91788.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WWK9
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
