Human Gene ARHGEF7 (ENST00000375736.8) from GENCODE V44
Description: Homo sapiens Rho guanine nucleotide exchange factor 7 (ARHGEF7), transcript variant 1, mRNA. (from RefSeq NM_003899) RefSeq Summary (NM_003899): This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]. Gencode Transcript: ENST00000375736.8 Gencode Gene: ENSG00000102606.20 Transcript (Including UTRs) Position: hg38 chr13:111,153,738-111,305,731 Size: 151,994 Total Exon Count: 20 Strand: + Coding Region Position: hg38 chr13:111,217,682-111,303,113 Size: 85,432 Coding Exon Count: 17
ID:ARHG7_HUMAN DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 7; AltName: Full=Beta-Pix; AltName: Full=COOL-1; AltName: Full=PAK-interacting exchange factor beta; AltName: Full=p85; FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. SUBUNIT: Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. INTERACTION: Q9Y2X7:GIT1; NbExp=2; IntAct=EBI-717515, EBI-466061; P41227:NAA10; NbExp=3; IntAct=EBI-717515, EBI-747693; SUBCELLULAR LOCATION: Cell junction, focal adhesion (By similarity). Cell projection, ruffle (By similarity). Cytoplasm, cell cortex (By similarity). Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. PTM: Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAH50521.1; Type=Erroneous initiation; Sequence=BAA09763.2; Type=Erroneous initiation; Sequence=CAD38906.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14155
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
