Human Gene RNASE1 (ENST00000397970.4) from GENCODE V44
Description: Homo sapiens ribonuclease A family member 1, pancreatic (RNASE1), transcript variant 1, mRNA. (from RefSeq NM_198235) RefSeq Summary (NM_198235): This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000397970.4 Gencode Gene: ENSG00000129538.14 Transcript (Including UTRs) Position: hg38 chr14:20,801,460-20,802,848 Size: 1,389 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr14:20,801,598-20,802,068 Size: 471 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.