Human Gene SLC39A2 (ENST00000298681.5) from GENCODE V44
Description: Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA. (from RefSeq NM_014579) RefSeq Summary (NM_014579): This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]. Gencode Transcript: ENST00000298681.5 Gencode Gene: ENSG00000165794.10 Transcript (Including UTRs) Position: hg38 chr14:20,999,293-21,001,871 Size: 2,579 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr14:20,999,447-21,001,579 Size: 2,133 Coding Exon Count: 4
ID:S39A2_HUMAN DESCRIPTION: RecName: Full=Zinc transporter ZIP2; AltName: Full=6A1; AltName: Full=Eti-1; AltName: Full=Solute carrier family 39 member 2; AltName: Full=Zrt- and Irt-like protein 2; Short=ZIP-2; Short=hZIP2; FUNCTION: Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed only in prostate and uterine epithelial cells. INDUCTION: Shows a dramatic induction in normal epithelial cells contact inhibition. MISCELLANEOUS: Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu(2+), Co(2+) and Mn(2+) ions. Not inhibited by Fe(2+). SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NP94
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK314974 - Homo sapiens cDNA, FLJ95890, highly similar to Homo sapiens solute carrier family 39 (zinc transporter), member 2 (SLC39A2), mRNA. AF186081 - Homo sapiens zinc transporter hZIP2 (hZIP2) mRNA, complete cds. JD436487 - Sequence 417511 from Patent EP1572962. D83039 - Homo sapiens eti-1 mRNA, complete cds. JD338065 - Sequence 319089 from Patent EP1572962. JD464538 - Sequence 445562 from Patent EP1572962. JD493084 - Sequence 474108 from Patent EP1572962. BC096723 - Homo sapiens solute carrier family 39 (zinc transporter), member 2, mRNA (cDNA clone MGC:119193 IMAGE:40004409), complete cds. BC098254 - Homo sapiens solute carrier family 39 (zinc transporter), member 2, mRNA (cDNA clone MGC:119191 IMAGE:40004407), complete cds. BC098274 - Homo sapiens solute carrier family 39 (zinc transporter), member 2, mRNA (cDNA clone IMAGE:40004408), containing frame-shift errors. BC110057 - Homo sapiens solute carrier family 39 (zinc transporter), member 2, mRNA (cDNA clone MGC:119190 IMAGE:40004405), complete cds. JD103801 - Sequence 84825 from Patent EP1572962. AB527985 - Synthetic construct DNA, clone: pF1KB6423, Homo sapiens SLC39A2 gene for solute carrier family 39 (zinc transporter), member 2, without stop codon, in Flexi system. KJ898762 - Synthetic construct Homo sapiens clone ccsbBroadEn_08156 SLC39A2 gene, encodes complete protein. AY029483 - Homo sapiens putative zinc uptake transporter 2 (ZIP2) mRNA, partial cds. JD541804 - Sequence 522828 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NP94 (Reactome details) participates in the following event(s):
R-HSA-442422 SLC39A1-4 transports Zn2+ from extracellular region to cytosol R-HSA-442380 Zinc influx into cells by the SLC39 gene family R-HSA-435354 Zinc transporters R-HSA-425410 Metal ion SLC transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
