Human Gene HAUS4 (ENST00000347758.6) from GENCODE V44
Description: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. (from UniProt Q9H6D7) RefSeq Summary (NM_001166269): This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]. Gencode Transcript: ENST00000347758.6 Gencode Gene: ENSG00000092036.19 Transcript (Including UTRs) Position: hg38 chr14:22,946,236-22,957,148 Size: 10,913 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr14:22,946,525-22,955,154 Size: 8,630 Coding Exon Count: 6
ID:HAUS4_HUMAN DESCRIPTION: RecName: Full=HAUS augmin-like complex subunit 4; FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. SUBUNIT: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. SIMILARITY: Belongs to the HAUS4 family. SEQUENCE CAUTION: Sequence=CAD62584.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H6D7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC002554 - Homo sapiens chromosome 14 open reading frame 94, mRNA (cDNA clone MGC:1046 IMAGE:3139198), complete cds. BX247995 - human full-length cDNA clone CS0DH003YP08 of T cells (Jurkat cell line) of Homo sapiens (human). AK000431 - Homo sapiens cDNA FLJ20424 fis, clone KAT02627. AK057779 - Homo sapiens cDNA FLJ25050 fis, clone CBL04077. AK026016 - Homo sapiens cDNA: FLJ22363 fis, clone HRC06574. BC001916 - Homo sapiens chromosome 14 open reading frame 94, mRNA (cDNA clone MGC:3455 IMAGE:2905474), complete cds. BX248256 - human full-length cDNA clone CS0DH005YD09 of T cells (Jurkat cell line) of Homo sapiens (human). BX247981 - human full-length cDNA clone CS0DF027YJ14 of Fetal brain of Homo sapiens (human). AY927599 - Homo sapiens mRNA sequence. JD133446 - Sequence 114470 from Patent EP1572962. JD349181 - Sequence 330205 from Patent EP1572962. JD290713 - Sequence 271737 from Patent EP1572962. JD465523 - Sequence 446547 from Patent EP1572962. JD258327 - Sequence 239351 from Patent EP1572962. JF432686 - Synthetic construct Homo sapiens clone IMAGE:100073924 chromosome 14 open reading frame 94 (C14orf94) gene, encodes complete protein. KJ894092 - Synthetic construct Homo sapiens clone ccsbBroadEn_03486 HAUS4 gene, encodes complete protein. JD026690 - Sequence 7714 from Patent EP1572962. JD029356 - Sequence 10380 from Patent EP1572962. AK097980 - Homo sapiens cDNA FLJ40661 fis, clone THYMU2019813. LQ980365 - Sequence 11 from Patent WO2013050532. HZ409511 - JP 2015528002-A/2108: CHIRAL CONTROL. HZ459682 - WO 2015182781-A/385: Kit or device and method for detecting pancreatic cancer. HZ460214 - WO 2015190542-A/220: Kit or device and method for detecting biliary tract cancer. HZ460728 - WO 2015190584-A/225: Kit or device and method for detecting prostate cancer. HZ461444 - WO 2015190586-A/257: Kit and method for detecting colon cancer. HZ462192 - WO 2015190591-A/347: Kit and method for detecting breast cancer. HZ463208 - WO 2015194535-A/302: Kit and method for detecting stomach cancer. HZ463551 - WO 2015194535-A/645: Kit and method for detecting stomach cancer. HZ464547 - WO 2015194615-A/365: Kit or device and method for detecting hepatic cancer. HZ465285 - WO 2015194627-A/338: Kit and method for detecting esophageal cancer. LG052845 - KR 1020150036642-A/2111: CHIRAL CONTROL. LP896726 - Sequence 1590 from Patent EP3253886. LY481122 - KR 1020170010856-A/385: PANCREATIC CANCER DETECTION KIT, DEVICE, AND DETECTION METHOD. LY495841 - KR 1020170015509-A/220: DETECTION KIT OR DEVICE AND DETECTION METHOD FOR BILIARY TRACT CANCER. LY496468 - KR 1020170018406-A/338: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY497087 - KR 1020170016485-A/257: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498448 - KR 1020170018411-A/365: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY499195 - KR 1020170018412-A/347: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500021 - KR 1020170019425-A/302: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500364 - KR 1020170019425-A/645: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500601 - KR 1020170016490-A/225: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238731 - WO 2017171048-A/392: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. LZ238744 - WO 2017171048-A/405: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS869006 - Sequence 220 from Patent EP3156500. MS869520 - Sequence 225 from Patent EP3156483. MS880510 - Sequence 347 from Patent EP3156498. MS884274 - Sequence 257 from Patent EP3156499. MS885140 - Sequence 302 from Patent EP3156503. MS885483 - Sequence 645 from Patent EP3156503. MS994476 - Sequence 338 from Patent EP3159406. FR772975 - Homo sapiens microRNA hsa-miR-4707-3p. HZ460566 - WO 2015190584-A/63: Kit or device and method for detecting prostate cancer. HZ461918 - WO 2015190591-A/73: Kit and method for detecting breast cancer. HZ463543 - WO 2015194535-A/637: Kit and method for detecting stomach cancer. HZ465111 - WO 2015194627-A/164: Kit and method for detecting esophageal cancer. HZ481851 - JP 2015535430-A/2357: TERMINALLY MODIFIED RNA. HZ791782 - JP 2016504050-A/3527: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JC514514 - Sequence 4767 from Patent WO2014113089. LF161133 - JP 2016513950-A/1199: Oligomers with improved off-target profile. LQ072102 - Sequence 2426 from Patent EP2964234. LY496294 - KR 1020170018406-A/164: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498921 - KR 1020170018412-A/73: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500356 - KR 1020170019425-A/637: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500439 - KR 1020170016490-A/63: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238487 - WO 2017171048-A/148: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MA406046 - WO 2018155427-A/820: A probe with reduced false positive binding, a method to desing the probe, and the use thereof. MA645603 - JP 2017113010-A/3527: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA733487 - JP 2017140048-A/2357: TERMINALLY MODIFIED RNA. MS869358 - Sequence 63 from Patent EP3156483. MS880236 - Sequence 73 from Patent EP3156498. MS885475 - Sequence 637 from Patent EP3156503. MS994302 - Sequence 164 from Patent EP3159406. HZ460945 - WO 2015190584-A/442: Kit or device and method for detecting prostate cancer. HZ462470 - WO 2015190591-A/625: Kit and method for detecting breast cancer. HZ463558 - WO 2015194535-A/652: Kit and method for detecting stomach cancer. HZ465555 - WO 2015194627-A/608: Kit and method for detecting esophageal cancer. LY496738 - KR 1020170018406-A/608: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY499473 - KR 1020170018412-A/625: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500371 - KR 1020170019425-A/652: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500818 - KR 1020170016490-A/442: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ239018 - WO 2017171048-A/679: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS869737 - Sequence 442 from Patent EP3156483. MS880788 - Sequence 625 from Patent EP3156498. MS885490 - Sequence 652 from Patent EP3156503. MS994746 - Sequence 608 from Patent EP3159406. JD223467 - Sequence 204491 from Patent EP1572962. FR772976 - Homo sapiens microRNA hsa-miR-4707-5p. HZ459647 - WO 2015182781-A/350: Kit or device and method for detecting pancreatic cancer. HZ459719 - WO 2015182781-A/422: Kit or device and method for detecting pancreatic cancer. HZ460064 - WO 2015190542-A/70: Kit or device and method for detecting biliary tract cancer. HZ460362 - WO 2015190542-A/368: Kit or device and method for detecting biliary tract cancer. HZ460542 - WO 2015190584-A/39: Kit or device and method for detecting prostate cancer. HZ460919 - WO 2015190584-A/416: Kit or device and method for detecting prostate cancer. HZ461250 - WO 2015190586-A/63: Kit and method for detecting colon cancer. HZ461633 - WO 2015190586-A/446: Kit and method for detecting colon cancer. HZ463009 - WO 2015194535-A/103: Kit and method for detecting stomach cancer. HZ463411 - WO 2015194535-A/505: Kit and method for detecting stomach cancer. HZ464329 - WO 2015194615-A/147: Kit or device and method for detecting hepatic cancer. HZ464784 - WO 2015194615-A/602: Kit or device and method for detecting hepatic cancer. HZ465071 - WO 2015194627-A/124: Kit and method for detecting esophageal cancer. HZ465499 - WO 2015194627-A/552: Kit and method for detecting esophageal cancer. HZ481852 - JP 2015535430-A/2358: TERMINALLY MODIFIED RNA. HZ791783 - JP 2016504050-A/3528: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JC514515 - Sequence 4768 from Patent WO2014113089. LF160850 - JP 2016513950-A/916: Oligomers with improved off-target profile. LF632704 - WO 2016117582-A/133: miRNA biomarkers for mental disorders. LQ072103 - Sequence 2427 from Patent EP2964234. LQ724711 - Sequence 344 from Patent WO2018096084. LY481087 - KR 1020170010856-A/350: PANCREATIC CANCER DETECTION KIT, DEVICE, AND DETECTION METHOD. LY481159 - KR 1020170010856-A/422: PANCREATIC CANCER DETECTION KIT, DEVICE, AND DETECTION METHOD. LY495691 - KR 1020170015509-A/70: DETECTION KIT OR DEVICE AND DETECTION METHOD FOR BILIARY TRACT CANCER. LY495989 - KR 1020170015509-A/368: DETECTION KIT OR DEVICE AND DETECTION METHOD FOR BILIARY TRACT CANCER. LY496254 - KR 1020170018406-A/124: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY496682 - KR 1020170018406-A/552: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY496893 - KR 1020170016485-A/63: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY497276 - KR 1020170016485-A/446: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498230 - KR 1020170018411-A/147: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY498685 - KR 1020170018411-A/602: LIVER CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY499822 - KR 1020170019425-A/103: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500224 - KR 1020170019425-A/505: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500415 - KR 1020170016490-A/39: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500792 - KR 1020170016490-A/416: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238474 - WO 2017171048-A/135: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. LZ239002 - WO 2017171048-A/663: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MA406096 - WO 2018155427-A/870: A probe with reduced false positive binding, a method to desing the probe, and the use thereof. MA645604 - JP 2017113010-A/3528: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA733488 - JP 2017140048-A/2358: TERMINALLY MODIFIED RNA. MS868856 - Sequence 70 from Patent EP3156500. MS869154 - Sequence 368 from Patent EP3156500. MS869334 - Sequence 39 from Patent EP3156483. MS869711 - Sequence 416 from Patent EP3156483. MS884080 - Sequence 63 from Patent EP3156499. MS884463 - Sequence 446 from Patent EP3156499. MS884941 - Sequence 103 from Patent EP3156503. MS885343 - Sequence 505 from Patent EP3156503. MS994262 - Sequence 124 from Patent EP3159406. MS994690 - Sequence 552 from Patent EP3159406. JD104596 - Sequence 85620 from Patent EP1572962. JD555286 - Sequence 536310 from Patent EP1572962. JD408486 - Sequence 389510 from Patent EP1572962. MA806146 - WO 2018199275-A/406: Kit, device and method for detection of ovary tumor. MA802656 - JP 2018183181-A/3527: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA802657 - JP 2018183181-A/3528: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA805870 - WO 2018199275-A/130: Kit, device and method for detection of ovary tumor. MA806425 - WO 2018199275-A/685: Kit, device and method for detection of ovary tumor. MA822590 - WO 2019004436-A/403: Kit, device, and method for detection of lung cancer. MA822254 - WO 2019004436-A/67: Kit, device, and method for detection of lung cancer. LY616495 - KR 1020180129785-A/392: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616508 - KR 1020180129785-A/405: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616251 - KR 1020180129785-A/148: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616782 - KR 1020180129785-A/679: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616238 - KR 1020180129785-A/135: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. LY616766 - KR 1020180129785-A/663: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. MB472953 - WO 2019208671-A/352: Kit or device and method for detecting bladder cancer. MB472954 - WO 2019208671-A/353: Kit or device and method for detecting bladder cancer. MB472718 - WO 2019208671-A/117: Kit or device and method for detecting bladder cancer. MB473185 - WO 2019208671-A/584: Kit or device and method for detecting bladder cancer. MB472719 - WO 2019208671-A/118: Kit or device and method for detecting bladder cancer. MB473186 - WO 2019208671-A/585: Kit or device and method for detecting bladder cancer.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H6D7 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
US Server
