Human Gene SLC10A1 (ENST00000216540.5) from GENCODE V44
Description: Homo sapiens solute carrier family 10 member 1 (SLC10A1), mRNA. (from RefSeq NM_003049) RefSeq Summary (NM_003049): The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000216540.5 Gencode Gene: ENSG00000100652.5 Transcript (Including UTRs) Position: hg38 chr14:69,775,416-69,797,241 Size: 21,826 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr14:69,776,282-69,797,155 Size: 20,874 Coding Exon Count: 5
ID:NTCP_HUMAN DESCRIPTION: RecName: Full=Sodium/bile acid cotransporter; AltName: Full=Cell growth-inhibiting gene 29 protein; AltName: Full=Na(+)/bile acid cotransporter; AltName: Full=Na(+)/taurocholate transport protein; AltName: Full=Sodium/taurocholate cotransporting polypeptide; AltName: Full=Solute carrier family 10 member 1; FUNCTION: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01758 - Sodium Bile acid symporter family
ModBase Predicted Comparative 3D Structure on Q14973
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.