ID:ACOT1_HUMAN DESCRIPTION: RecName: Full=Acyl-coenzyme A thioesterase 1; Short=Acyl-CoA thioesterase 1; EC=3.1.2.2; AltName: Full=CTE-I; AltName: Full=CTE-Ib; AltName: Full=Inducible cytosolic acyl-coenzyme A thioester hydrolase; AltName: Full=Long chain acyl-CoA thioester hydrolase; Short=Long chain acyl-CoA hydrolase; FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity). CATALYTIC ACTIVITY: Palmitoyl-CoA + H(2)O = CoA + palmitate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=35.8 uM for C10-acyl-CoA; KM=3.6 uM for C12-acyl-CoA; KM=2.8 uM for C14-acyl-CoA; KM=3.6 uM for C16-acyl-CoA; KM=2.4 uM for C18-acyl-CoA; KM=2 uM for C20-acyl-CoA; KM=2.4 uM for C16:1-acyl-CoA; KM=4.1 uM for C18:1-acyl-CoA; KM=2.1 uM for C18:1-trans-acyl-CoA; Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA; Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA; Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA; Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA; SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08840 - BAAT / Acyl-CoA thioester hydrolase C terminal PF04775 - Acyl-CoA thioester hydrolase/BAAT N-terminal region
ModBase Predicted Comparative 3D Structure on Q86TX2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000038 very long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process GO:0006637 acyl-CoA metabolic process
US Server
