Human Gene ITPKA (ENST00000260386.7) from GENCODE V44
Description: Homo sapiens inositol-trisphosphate 3-kinase A (ITPKA), mRNA. (from RefSeq NM_002220) RefSeq Summary (NM_002220): Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000260386.7 Gencode Gene: ENSG00000137825.11 Transcript (Including UTRs) Position: hg38 chr15:41,493,874-41,503,551 Size: 9,678 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr15:41,493,928-41,503,166 Size: 9,239 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23677
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC026331 - Homo sapiens inositol 1,4,5-trisphosphate 3-kinase A, mRNA (cDNA clone MGC:26387 IMAGE:4792595), complete cds. X54938 - Human mRNA for inositol 1,4,5-triphosphate 3-kinase. AB463780 - Synthetic construct DNA, clone: pF1KB8104, Homo sapiens ITPKA gene for inositol 1,4,5-trisphosphate 3-kinase A, without stop codon, in Flexi system. JD159148 - Sequence 140172 from Patent EP1572962. JD462981 - Sequence 444005 from Patent EP1572962. JD134750 - Sequence 115774 from Patent EP1572962. JD187778 - Sequence 168802 from Patent EP1572962. JD269018 - Sequence 250042 from Patent EP1572962. JD430842 - Sequence 411866 from Patent EP1572962. JD409764 - Sequence 390788 from Patent EP1572962. JD509484 - Sequence 490508 from Patent EP1572962. JD340262 - Sequence 321286 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00562 - Inositol phosphate metabolism hsa01100 - Metabolic pathways hsa04020 - Calcium signaling pathway hsa04070 - Phosphatidylinositol signaling system
BioCyc Knowledge Library PWY-6358 - superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism PWY-6362 - 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) PWY-6364 - D-myo-inositol (1,3,4)-trisphosphate biosynthesis PWY-6371 - superpathway of inositol phosphate compounds
Reactome (by CSHL, EBI, and GO)
Protein P23677 (Reactome details) participates in the following event(s):
R-HSA-1855153 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol R-HSA-1483249 Inositol phosphate metabolism R-HSA-1430728 Metabolism
US Server
