Human Gene RASGRF1 (ENST00000394745.3) from GENCODE V44
Description: Homo sapiens Ras protein specific guanine nucleotide releasing factor 1 (RASGRF1), transcript variant 2, mRNA. (from RefSeq NM_153815) RefSeq Summary (NM_153815): The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000394745.3 Gencode Gene: ENSG00000058335.16 Transcript (Including UTRs) Position: hg38 chr15:78,961,942-79,005,665 Size: 43,724 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr15:78,962,144-79,003,946 Size: 41,803 Coding Exon Count: 13
ID:RGRF1_HUMAN DESCRIPTION: RecName: Full=Ras-specific guanine nucleotide-releasing factor 1; Short=Ras-GRF1; AltName: Full=Guanine nucleotide-releasing protein; Short=GNRP; AltName: Full=Ras-specific nucleotide exchange factor CDC25; FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. SUBUNIT: Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability (By similarity). DOMAIN: The DH (DBL-homology) domain mediates interaction with RASGRF2. PTM: Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome (By similarity). PTM: Ubiquitinated and degraded following phosphorylation by PLK2 (By similarity). PTM: Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 IQ domain. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 2 PH domains. SIMILARITY: Contains 1 Ras-GEF domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RASGRF1ID43453ch15q25.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13972
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction GO:0007616 long-term memory GO:0008283 cell proliferation GO:0031175 neuron projection development GO:0034976 response to endoplasmic reticulum stress GO:0035020 regulation of Rac protein signal transduction GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043547 positive regulation of GTPase activity GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0048167 regulation of synaptic plasticity GO:0048168 regulation of neuronal synaptic plasticity GO:0090630 activation of GTPase activity GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
US Server
