Human Gene CERS3 (ENST00000538112.6) from GENCODE V44
Description: Homo sapiens ceramide synthase 3 (CERS3), transcript variant 2, mRNA. (from RefSeq NM_001290342) RefSeq Summary (NM_001290342): This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. Gencode Transcript: ENST00000538112.6 Gencode Gene: ENSG00000154227.14 Transcript (Including UTRs) Position: hg38 chr15:100,402,511-100,544,271 Size: 141,761 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr15:100,402,713-100,501,849 Size: 99,137 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IU89
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0016740 transferase activity GO:0050291 sphingosine N-acyltransferase activity
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006629 lipid metabolic process GO:0030148 sphingolipid biosynthetic process GO:0030216 keratinocyte differentiation GO:0046513 ceramide biosynthetic process
US Server
