ID:AL1A3_HUMAN DESCRIPTION: RecName: Full=Aldehyde dehydrogenase family 1 member A3; EC=1.2.1.5; AltName: Full=Aldehyde dehydrogenase 6; AltName: Full=Retinaldehyde dehydrogenase 3; Short=RALDH-3; Short=RalDH3; FUNCTION: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity). CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H. PATHWAY: Cofactor metabolism; retinol metabolism. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney. SIMILARITY: Belongs to the aldehyde dehydrogenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00171 - Aldehyde dehydrogenase family
ModBase Predicted Comparative 3D Structure on P47895
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001758 retinal dehydrogenase activity GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042803 protein homodimerization activity GO:0070324 thyroid hormone binding GO:0070403 NAD+ binding
Biological Process: GO:0002072 optic cup morphogenesis involved in camera-type eye development GO:0002138 retinoic acid biosynthetic process GO:0007626 locomotory behavior GO:0008152 metabolic process GO:0021768 nucleus accumbens development GO:0031076 embryonic camera-type eye development GO:0042472 inner ear morphogenesis GO:0042572 retinol metabolic process GO:0042573 retinoic acid metabolic process GO:0042574 retinal metabolic process GO:0043065 positive regulation of apoptotic process GO:0043584 nose development GO:0048048 embryonic eye morphogenesis GO:0050885 neuromuscular process controlling balance GO:0051289 protein homotetramerization GO:0055114 oxidation-reduction process GO:0060013 righting reflex GO:0060166 olfactory pit development GO:0060324 face development GO:0070384 Harderian gland development
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
