Human Gene FAM234A (ENST00000301678.7) from GENCODE V44
  Description: Membrane; Single-pass type II membrane protein (Potential). (from UniProt Q9H0X4)
Gencode Transcript: ENST00000301678.7
Gencode Gene: ENSG00000167930.17
Transcript (Including UTRs)
   Position: hg38 chr16:234,846-266,120 Size: 31,275 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr16:254,414-265,022 Size: 10,609 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:234,846-266,120)mRNA (may differ from genome)Protein (552 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGencodeGeneCardsHPRDLynx
MalacardsMGIneXtProtPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ITFG3_HUMAN
DESCRIPTION: RecName: Full=Protein ITFG3;
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the ITFG3 family.
SEQUENCE CAUTION: Sequence=AAK61220.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 39.29 RPKM in Nerve - Tibial
Total median expression: 1056.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.30144-0.349 Picture PostScript Text
3' UTR -449.701098-0.410 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011047 - Quinonprotein_ADH-like

ModBase Predicted Comparative 3D Structure on Q9H0X4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI Ensembl   
Protein Sequence Protein Sequence   
Alignment Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK310766 - Homo sapiens cDNA, FLJ17808.
AK057165 - Homo sapiens cDNA FLJ32603 fis, clone STOMA1000117.
AL136542 - Homo sapiens mRNA; cDNA DKFZp761D0211 (from clone DKFZp761D0211).
AK294581 - Homo sapiens cDNA FLJ60496 complete cds.
BC032112 - Homo sapiens integrin alpha FG-GAP repeat containing 3, mRNA (cDNA clone MGC:23152 IMAGE:4844625), complete cds.
BC013047 - Homo sapiens integrin alpha FG-GAP repeat containing 3, mRNA (cDNA clone MGC:9779 IMAGE:3857041), complete cds.
AM393647 - Synthetic construct Homo sapiens clone IMAGE:100001683 for hypothetical protein (ITFG3 gene).
KJ899747 - Synthetic construct Homo sapiens clone ccsbBroadEn_09141 ITFG3 gene, encodes complete protein.
BC010521 - Homo sapiens integrin alpha FG-GAP repeat containing 3, mRNA (cDNA clone IMAGE:4151114), partial cds.
BC009214 - Homo sapiens integrin alpha FG-GAP repeat containing 3, mRNA (cDNA clone IMAGE:3690419), containing frame-shift errors.
JD115048 - Sequence 96072 from Patent EP1572962.
DQ592329 - Homo sapiens piRNA piR-59441, complete sequence.
JD502480 - Sequence 483504 from Patent EP1572962.
JD143277 - Sequence 124301 from Patent EP1572962.
JD227262 - Sequence 208286 from Patent EP1572962.
JD216792 - Sequence 197816 from Patent EP1572962.
JD474587 - Sequence 455611 from Patent EP1572962.
JD156621 - Sequence 137645 from Patent EP1572962.
JD393357 - Sequence 374381 from Patent EP1572962.
JD121549 - Sequence 102573 from Patent EP1572962.
JD271051 - Sequence 252075 from Patent EP1572962.
JD132763 - Sequence 113787 from Patent EP1572962.
JD418627 - Sequence 399651 from Patent EP1572962.
JD493545 - Sequence 474569 from Patent EP1572962.
JD493546 - Sequence 474570 from Patent EP1572962.
JD120012 - Sequence 101036 from Patent EP1572962.
JD219262 - Sequence 200286 from Patent EP1572962.
JD278148 - Sequence 259172 from Patent EP1572962.
JD317793 - Sequence 298817 from Patent EP1572962.
JD104804 - Sequence 85828 from Patent EP1572962.
JD176691 - Sequence 157715 from Patent EP1572962.
JD450040 - Sequence 431064 from Patent EP1572962.
JD470948 - Sequence 451972 from Patent EP1572962.
JD418243 - Sequence 399267 from Patent EP1572962.
JD063795 - Sequence 44819 from Patent EP1572962.
JD390213 - Sequence 371237 from Patent EP1572962.
JD123854 - Sequence 104878 from Patent EP1572962.
JD310531 - Sequence 291555 from Patent EP1572962.
JD525503 - Sequence 506527 from Patent EP1572962.
JD402409 - Sequence 383433 from Patent EP1572962.
JD535704 - Sequence 516728 from Patent EP1572962.
JD133318 - Sequence 114342 from Patent EP1572962.
JD152471 - Sequence 133495 from Patent EP1572962.
JD187307 - Sequence 168331 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AL136542, C16orf9, D3DU45, ENST00000301678.1, ENST00000301678.2, ENST00000301678.3, ENST00000301678.4, ENST00000301678.5, ENST00000301678.6, ITFG3, ITFG3_HUMAN, Q7L416, Q96FR1, Q96MC7, Q96S30, Q9H0X4, uc002cgh.1, uc002cgh.2, uc002cgh.3, uc002cgh.4, uc002cgh.5
UCSC ID: ENST00000301678.7
RefSeq Accession: NM_001284497
Protein: Q9H0X4 (aka ITFG3_HUMAN)
CCDS: CCDS10402.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.