Human Gene GGA2 (ENST00000309859.8) from GENCODE V44
Description: Homo sapiens golgi associated, gamma adaptin ear containing, ARF binding protein 2 (GGA2), mRNA. (from RefSeq NM_015044) RefSeq Summary (NM_015044): This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000309859.8 Gencode Gene: ENSG00000103365.15 Transcript (Including UTRs) Position: hg38 chr16:23,463,542-23,510,494 Size: 46,953 Total Exon Count: 17 Strand: - Coding Region Position: hg38 chr16:23,467,590-23,510,411 Size: 42,822 Coding Exon Count: 17
ID:GGA2_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor-binding protein GGA2; AltName: Full=Gamma-adaptin-related protein 2; AltName: Full=Golgi-localized, gamma ear-containing, ARF-binding protein 2; AltName: Full=VHS domain and ear domain of gamma-adaptin; Short=Vear; FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. SUBUNIT: Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2. INTERACTION: Q15276:RABEP1; NbExp=6; IntAct=EBI-447646, EBI-447043; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif). DOMAIN: The GAT domain is responsible for interaction with ARF- GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis. DOMAIN: The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs. DOMAIN: The GAE domain binds accessory proteins regulating GGAs function. PTM: Ubiquitinated (By similarity). SIMILARITY: Belongs to the GGA protein family. SIMILARITY: Contains 1 GAE domain. SIMILARITY: Contains 1 GAT domain. SIMILARITY: Contains 1 VHS domain. SEQUENCE CAUTION: Sequence=AAK38634.1; Type=Frameshift; Positions=193;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UJY4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0030306 ADP-ribosylation factor binding
Biological Process: GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0044267 cellular protein metabolic process
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