Human Gene CTF1 (ENST00000279804.3) from GENCODE V44
Description: Homo sapiens cardiotrophin 1 (CTF1), transcript variant 3, non-coding RNA. (from RefSeq NR_165660) RefSeq Summary (NR_165660): The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. Gencode Transcript: ENST00000279804.3 Gencode Gene: ENSG00000150281.7 Transcript (Including UTRs) Position: hg38 chr16:30,896,614-30,903,547 Size: 6,934 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr16:30,896,644-30,902,539 Size: 5,896 Coding Exon Count: 3
ID:CTF1_HUMAN DESCRIPTION: RecName: Full=Cardiotrophin-1; Short=CT-1; FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes. SIMILARITY: Belongs to the IL-6 superfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16619
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007166 cell surface receptor signaling pathway GO:0007267 cell-cell signaling GO:0007399 nervous system development GO:0007517 muscle organ development GO:0008283 cell proliferation GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0048666 neuron development GO:0048861 leukemia inhibitory factor signaling pathway
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
BC064416 - Homo sapiens cardiotrophin 1, mRNA (cDNA clone MGC:70822 IMAGE:5750481), complete cds. U43030 - Homo sapiens cardiotrophin-1 (CTF1) mRNA, complete cds. JD395528 - Sequence 376552 from Patent EP1572962. BC049822 - Homo sapiens cardiotrophin 1, mRNA (cDNA clone IMAGE:5806399). BC036787 - Homo sapiens cardiotrophin 1, mRNA (cDNA clone MGC:46223 IMAGE:5754188), complete cds. JD333859 - Sequence 314883 from Patent EP1572962. JD394458 - Sequence 375482 from Patent EP1572962. JD161735 - Sequence 142759 from Patent EP1572962. JD293790 - Sequence 274814 from Patent EP1572962. JD402894 - Sequence 383918 from Patent EP1572962. JD498766 - Sequence 479790 from Patent EP1572962. JD219765 - Sequence 200789 from Patent EP1572962. JD228844 - Sequence 209868 from Patent EP1572962. JD259736 - Sequence 240760 from Patent EP1572962. JD255764 - Sequence 236788 from Patent EP1572962. JD131789 - Sequence 112813 from Patent EP1572962. JD072897 - Sequence 53921 from Patent EP1572962. JD071952 - Sequence 52976 from Patent EP1572962. JD293491 - Sequence 274515 from Patent EP1572962. JD520690 - Sequence 501714 from Patent EP1572962. JD408885 - Sequence 389909 from Patent EP1572962. JD448026 - Sequence 429050 from Patent EP1572962. JD070285 - Sequence 51309 from Patent EP1572962. JD397973 - Sequence 378997 from Patent EP1572962. JD416489 - Sequence 397513 from Patent EP1572962. JD272986 - Sequence 254010 from Patent EP1572962. JD092148 - Sequence 73172 from Patent EP1572962. JD535811 - Sequence 516835 from Patent EP1572962. JD432094 - Sequence 413118 from Patent EP1572962. JD080088 - Sequence 61112 from Patent EP1572962. JD320540 - Sequence 301564 from Patent EP1572962. JD525570 - Sequence 506594 from Patent EP1572962. JD391912 - Sequence 372936 from Patent EP1572962. JD131938 - Sequence 112962 from Patent EP1572962. JD555202 - Sequence 536226 from Patent EP1572962. JD422989 - Sequence 404013 from Patent EP1572962. JD053020 - Sequence 34044 from Patent EP1572962. JD240894 - Sequence 221918 from Patent EP1572962. JD404939 - Sequence 385963 from Patent EP1572962. JD323470 - Sequence 304494 from Patent EP1572962. JD341569 - Sequence 322593 from Patent EP1572962. JD297970 - Sequence 278994 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04630 - Jak-STAT signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
Reactome (by CSHL, EBI, and GO)
Protein Q16619 (Reactome details) participates in the following event(s):
US Server
