ID:SL9A5_HUMAN DESCRIPTION: RecName: Full=Sodium/hydrogen exchanger 5; AltName: Full=Na(+)/H(+) exchanger 5; Short=NHE-5; AltName: Full=Solute carrier family 9 member 5; FUNCTION: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). SUBUNIT: Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in brain, testis, spleen, and skeletal muscle. PTM: Phosphorylated (Possible). SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. CAUTION: The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00999 - Sodium/hydrogen exchanger family
ModBase Predicted Comparative 3D Structure on Q14940
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
