Human Gene CFDP1 (ENST00000283882.4) from GENCODE V44
  Description: Homo sapiens craniofacial development protein 1 (CFDP1), mRNA. (from RefSeq NM_006324)
Gencode Transcript: ENST00000283882.4
Gencode Gene: ENSG00000153774.9
Transcript (Including UTRs)
   Position: hg38 chr16:75,293,710-75,433,503 Size: 139,794 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr16:75,293,952-75,433,352 Size: 139,401 Coding Exon Count: 7 

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RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:75,293,710-75,433,503)mRNA (may differ from genome)Protein (299 aa)
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-  Comments and Description Text from UniProtKB
  ID: CFDP1_HUMAN
DESCRIPTION: RecName: Full=Craniofacial development protein 1; AltName: Full=Bucentaur;
FUNCTION: May play a role during embryogenesis (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
PTM: Phosphorylated by CK2 (casein kinase II) in vitro.
SIMILARITY: Contains 1 BCNT-C domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CFDP1
Diseases sorted by gene-association score: acute stress disorder (16)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.56 RPKM in Testis
Total median expression: 789.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.40151-0.460 Picture PostScript Text
3' UTR -37.60242-0.155 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011421 - BCNT

Pfam Domains:
PF07572 - Bucentaur or craniofacial development

ModBase Predicted Comparative 3D Structure on Q9UEE9
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
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AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0007155 cell adhesion
GO:0007275 multicellular organism development
GO:0008150 biological_process
GO:0008360 regulation of cell shape
GO:0042127 regulation of cell proliferation
GO:2000270 negative regulation of fibroblast apoptotic process

Cellular Component:
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005575 cellular_component
GO:0005694 chromosome


-  Descriptions from all associated GenBank mRNAs
  BC000991 - Homo sapiens craniofacial development protein 1, mRNA (cDNA clone MGC:5126 IMAGE:3449836), complete cds.
AB009285 - Homo sapiens BCNT mRNA, complete cds.
D86549 - Homo sapiens bcnt mRNA for bucentaur, partial cds, clone:lambda-ZAPII #1.
AK226031 - Homo sapiens mRNA for craniofacial development protein 1 variant, clone: FCC104A11.
CR542111 - Homo sapiens full open reading frame cDNA clone RZPDo834G0737D for gene CFDP1, craniofacial development protein 1; complete cds, incl. stopcodon.
AK313948 - Homo sapiens cDNA, FLJ94590, highly similar to Homo sapiens craniofacial development protein 1 (CFDP1), mRNA.
KJ898210 - Synthetic construct Homo sapiens clone ccsbBroadEn_07604 CFDP1 gene, encodes complete protein.
BT009819 - Homo sapiens craniofacial development protein 1 mRNA, complete cds.
DQ890998 - Synthetic construct clone IMAGE:100003628; FLH168369.01X; RZPDo839F1292D craniofacial development protein 1 (CFDP1) gene, encodes complete protein.
EU176574 - Synthetic construct Homo sapiens clone IMAGE:100011364; FLH168368.01L; RZPDo839G12253D craniofacial development protein 1 (CFDP1) gene, encodes complete protein.
AB463545 - Synthetic construct DNA, clone: pF1KB6380, Homo sapiens CFDP1 gene for craniofacial development protein 1, without stop codon, in Flexi system.
CU674490 - Synthetic construct Homo sapiens gateway clone IMAGE:100018751 5' read CFDP1 mRNA.
JD236317 - Sequence 217341 from Patent EP1572962.
LC057683 - Homo sapiens CFDP1 mRNA for bucentaur, complete cds, note: BCNT-variant5.
LC057684 - Homo sapiens CFDP1 mRNA for bucentaur, complete cds, note: BCNT-variant6.
LC057679 - Homo sapiens CFDP1 mRNA for bucentaur, complete cds, note: BCNT-variant1.
LC057680 - Homo sapiens CFDP1 mRNA for bucentaur, complete cds, note: BCNT-variant2.
LC057681 - Homo sapiens CFDP1 mRNA for bucentaur, complete cds, note: BCNT-variant3.
LC057682 - Homo sapiens CFDP1 mRNA for bucentaur, complete cds, note: BCNT-variant4.
D85939 - Homo sapiens bcnt mRNA for bucentaur, complete cds, clone:hRACE#1.
JD117466 - Sequence 98490 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BCNT, CFDP1_HUMAN, ENST00000283882.1, ENST00000283882.2, ENST00000283882.3, NM_006324, O00393, O00404, Q9UEE9, Q9UEF0, Q9UEF1, Q9UEF8, uc002fdy.1, uc002fdy.2, uc002fdy.3, uc002fdy.4, uc002fdy.5
UCSC ID: ENST00000283882.4
RefSeq Accession: NM_006324
Protein: Q9UEE9 (aka CFDP1_HUMAN)
CCDS: CCDS10916.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.