Human Gene TMEM170A (ENST00000561878.2) from GENCODE V49
  Description: transmembrane protein 170A, transcript variant 1 (from RefSeq NM_145254.3)
Gencode Transcript: ENST00000561878.2
Gencode Gene: ENSG00000166822.14
Transcript (Including UTRs)
   Position: hg38 chr16:75,443,054-75,464,689 Size: 21,636 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr16:75,447,558-75,464,600 Size: 17,043 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2025-09-17 13:57:07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:75,443,054-75,464,689)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T170A_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 170A;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM170 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.23 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 201.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.8089-0.402 Picture PostScript Text
3' UTR -1351.124504-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019334 - Transmembrane_pr_170

Pfam Domains:
PF10190 - Putative transmembrane protein 170

ModBase Predicted Comparative 3D Structure on Q8WVE7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006998 nuclear envelope organization
GO:0051292 nuclear pore complex assembly
GO:0071786 endoplasmic reticulum tubular network organization

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC031860 - Homo sapiens cDNA clone IMAGE:4820528.
BX648484 - Homo sapiens mRNA; cDNA DKFZp686O1555 (from clone DKFZp686O1555).
BX648429 - Homo sapiens mRNA; cDNA DKFZp686C20253 (from clone DKFZp686C20253).
BX647432 - Homo sapiens mRNA; cDNA DKFZp686M03149 (from clone DKFZp686M03149).
JD275518 - Sequence 256542 from Patent EP1572962.
AK094930 - Homo sapiens cDNA FLJ37611 fis, clone BRCOC2011418.
JD095315 - Sequence 76339 from Patent EP1572962.
AK298475 - Homo sapiens cDNA FLJ52904 complete cds.
BC018082 - Homo sapiens transmembrane protein 170A, mRNA (cDNA clone MGC:26939 IMAGE:4796761), complete cds.
JD361346 - Sequence 342370 from Patent EP1572962.
JD093337 - Sequence 74361 from Patent EP1572962.
JD412267 - Sequence 393291 from Patent EP1572962.
JD556522 - Sequence 537546 from Patent EP1572962.
JD357297 - Sequence 338321 from Patent EP1572962.
JD429760 - Sequence 410784 from Patent EP1572962.
AY302139 - Homo sapiens unknown mRNA.
AK311919 - Homo sapiens cDNA, FLJ92186.
HQ448193 - Synthetic construct Homo sapiens clone IMAGE:100071589; CCSB001139_01 transmembrane protein 170 (TMEM170) gene, encodes complete protein.
KJ895391 - Synthetic construct Homo sapiens clone ccsbBroadEn_04785 TMEM170A gene, encodes complete protein.
CU676164 - Synthetic construct Homo sapiens gateway clone IMAGE:100023424 5' read TMEM170 mRNA.
AM392693 - Synthetic construct Homo sapiens clone IMAGE:100002281 for hypothetical protein (LOC124491 gene).
AM393662 - Synthetic construct Homo sapiens clone IMAGE:100002282 for hypothetical protein (LOC124491 gene).

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4R3, B4DPS4, D3DUK2, ENST00000561878.1, NM_145254, Q7Z6F3, Q8WVE7, T170A_HUMAN, TMEM170, uc002fee.1, uc002fee.2, uc002fee.3
UCSC ID: ENST00000561878.2
RefSeq Accession: NM_145254.3
Protein: Q8WVE7 (aka T170A_HUMAN)
CCDS: CCDS10917.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.