Human Gene CHD3 (ENST00000330494.12) from GENCODE V44
Description: Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA. (from RefSeq NM_001005273) RefSeq Summary (NM_001005273): This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000330494.12 Gencode Gene: ENSG00000170004.19 Transcript (Including UTRs) Position: hg38 chr17:7,888,789-7,912,755 Size: 23,967 Total Exon Count: 40 Strand: + Coding Region Position: hg38 chr17:7,889,001-7,911,585 Size: 22,585 Coding Exon Count: 40
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08074 - CHDCT2 (NUC038) domain PF08073 - CHDNT (NUC034) domain PF00385 - Chromo (CHRromatin Organisation MOdifier) domain PF06461 - Domain of Unknown Function (DUF1086) PF06465 - Domain of Unknown Function (DUF1087) PF00271 - Helicase conserved C-terminal domain PF00628 - PHD-finger PF00176 - SNF2 family N-terminal domain
ModBase Predicted Comparative 3D Structure on Q12873
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.