Human Gene NDEL1 (ENST00000402554.7) from GENCODE V44
Description: Homo sapiens nudE neurodevelopment protein 1 like 1 (NDEL1), transcript variant 1, mRNA. (from RefSeq NM_001025579) RefSeq Summary (NM_001025579): This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]. Gencode Transcript: ENST00000402554.7 Gencode Gene: ENSG00000166579.16 Transcript (Including UTRs) Position: hg38 chr17:8,435,908-8,467,658 Size: 31,751 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr17:8,444,272-8,466,937 Size: 22,666 Coding Exon Count: 9
ID:NDEL1_HUMAN DESCRIPTION: RecName: Full=Nuclear distribution protein nudE-like 1; Short=Protein Nudel; AltName: Full=Mitosin-associated protein 1; FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. SUBUNIT: Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C- terminus) with CENPF. Interacts with ZNF365. INTERACTION: P49454:CENPF; NbExp=5; IntAct=EBI-928842, EBI-968343; Q9NRI5:DISC1; NbExp=13; IntAct=EBI-928842, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. TISSUE SPECIFICITY: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. DEVELOPMENTAL STAGE: Expression peaks in mitosis. PTM: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE. PTM: Palmitoylation at Cys-273 reduces affinity for dynein. SIMILARITY: Belongs to the nudE family. CAUTION: Was originally (PubMed:15728732) thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZM8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF209113 - JP 2014500723-A/16616: Polycomb-Associated Non-Coding RNAs. MA444690 - JP 2018138019-A/16616: Polycomb-Associated Non-Coding RNAs. AK299559 - Homo sapiens cDNA FLJ55173 complete cds, highly similar to Nuclear distribution protein nudE-like 1. AF217798 - Homo sapiens endooligopeptidase A mRNA, complete cds. AK056014 - Homo sapiens cDNA FLJ31452 fis, clone NT2NE2001000, highly similar to Nuclear distribution protein nudE-like 1. BC026101 - Homo sapiens nudE nuclear distribution gene E homolog (A. nidulans)-like 1, mRNA (cDNA clone MGC:32953 IMAGE:4820855), complete cds. AF182078 - Homo sapiens mitosin-associated protein MITAP1 (MITAP1) mRNA, complete cds. AY004871 - Homo sapiens Nudel mRNA, complete cds. AL832648 - Homo sapiens mRNA; cDNA DKFZp451M0318 (from clone DKFZp451M0318). JD480267 - Sequence 461291 from Patent EP1572962. CU693134 - Synthetic construct Homo sapiens gateway clone IMAGE:100019034 5' read NDEL1 mRNA. HQ447858 - Synthetic construct Homo sapiens clone IMAGE:100071203; CCSB001734_02 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1) gene, encodes complete protein. KJ899678 - Synthetic construct Homo sapiens clone ccsbBroadEn_09072 NDEL1 gene, encodes complete protein. LF326253 - JP 2014500723-A/133756: Polycomb-Associated Non-Coding RNAs. MA561830 - JP 2018138019-A/133756: Polycomb-Associated Non-Coding RNAs. LF326251 - JP 2014500723-A/133754: Polycomb-Associated Non-Coding RNAs. MA561828 - JP 2018138019-A/133754: Polycomb-Associated Non-Coding RNAs. LF326250 - JP 2014500723-A/133753: Polycomb-Associated Non-Coding RNAs. MA561827 - JP 2018138019-A/133753: Polycomb-Associated Non-Coding RNAs. LF326249 - JP 2014500723-A/133752: Polycomb-Associated Non-Coding RNAs. MA561826 - JP 2018138019-A/133752: Polycomb-Associated Non-Coding RNAs. LF326248 - JP 2014500723-A/133751: Polycomb-Associated Non-Coding RNAs. MA561825 - JP 2018138019-A/133751: Polycomb-Associated Non-Coding RNAs. LF326247 - JP 2014500723-A/133750: Polycomb-Associated Non-Coding RNAs. MA561824 - JP 2018138019-A/133750: Polycomb-Associated Non-Coding RNAs. LF326245 - JP 2014500723-A/133748: Polycomb-Associated Non-Coding RNAs. MA561822 - JP 2018138019-A/133748: Polycomb-Associated Non-Coding RNAs. AF038203 - Homo sapiens clone 23596 mRNA sequence. LF326244 - JP 2014500723-A/133747: Polycomb-Associated Non-Coding RNAs. MA561821 - JP 2018138019-A/133747: Polycomb-Associated Non-Coding RNAs. LF326243 - JP 2014500723-A/133746: Polycomb-Associated Non-Coding RNAs. MA561820 - JP 2018138019-A/133746: Polycomb-Associated Non-Coding RNAs. AK123802 - Homo sapiens cDNA FLJ41808 fis, clone NOVAR2001783. AK128514 - Homo sapiens cDNA FLJ46671 fis, clone TRACH3008632. BC131748 - Homo sapiens cDNA clone IMAGE:40118222. AK095179 - Homo sapiens cDNA FLJ37860 fis, clone BRSSN2015493. LF326238 - JP 2014500723-A/133741: Polycomb-Associated Non-Coding RNAs. MA561815 - JP 2018138019-A/133741: Polycomb-Associated Non-Coding RNAs. JD418251 - Sequence 399275 from Patent EP1572962. JD223220 - Sequence 204244 from Patent EP1572962. JD544370 - Sequence 525394 from Patent EP1572962. JD148699 - Sequence 129723 from Patent EP1572962. JD319812 - Sequence 300836 from Patent EP1572962. JD152552 - Sequence 133576 from Patent EP1572962. JD493938 - Sequence 474962 from Patent EP1572962. JD377894 - Sequence 358918 from Patent EP1572962. JD497535 - Sequence 478559 from Patent EP1572962. JD192656 - Sequence 173680 from Patent EP1572962. JD261120 - Sequence 242144 from Patent EP1572962. JD362975 - Sequence 343999 from Patent EP1572962. JD241251 - Sequence 222275 from Patent EP1572962. JD142916 - Sequence 123940 from Patent EP1572962. JD345259 - Sequence 326283 from Patent EP1572962. JD250279 - Sequence 231303 from Patent EP1572962. JD123030 - Sequence 104054 from Patent EP1572962. JD359442 - Sequence 340466 from Patent EP1572962. JD237004 - Sequence 218028 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_Lis1Pathway - Lissencephaly gene (LIS1) in neuronal migration and development
Reactome (by CSHL, EBI, and GO)
Protein Q9GZM8 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
