Human Gene TMEM220 (ENST00000341871.8) from GENCODE V44
  Description: Homo sapiens transmembrane protein 220 (TMEM220), transcript variant 1, mRNA. (from RefSeq NM_001004313)
Gencode Transcript: ENST00000341871.8
Gencode Gene: ENSG00000187824.9
Transcript (Including UTRs)
   Position: hg38 chr17:10,713,295-10,730,023 Size: 16,729 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr17:10,715,453-10,729,851 Size: 14,399 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:10,713,295-10,730,023)mRNA (may differ from genome)Protein (160 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM220_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 220;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.76 RPKM in Liver
Total median expression: 150.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -76.70172-0.446 Picture PostScript Text
3' UTR -520.202158-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q6QAJ8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY550194 - Homo sapiens clone LOC_LELC unknown mRNA.
BC136838 - Homo sapiens transmembrane protein 220, mRNA (cDNA clone MGC:168452 IMAGE:9020829), complete cds.
BC136840 - Homo sapiens transmembrane protein 220, mRNA (cDNA clone MGC:168454 IMAGE:9020831), complete cds.
AK295928 - Homo sapiens cDNA FLJ50088 complete cds.
AK289624 - Homo sapiens cDNA FLJ76210 complete cds.
JD361371 - Sequence 342395 from Patent EP1572962.
BC127705 - Homo sapiens transmembrane protein 220, mRNA (cDNA clone MGC:157800 IMAGE:40127270), complete cds.
EF126147 - Homo sapiens transmembrane protein mRNA, complete cds.
KJ896184 - Synthetic construct Homo sapiens clone ccsbBroadEn_05578 TMEM220 gene, encodes complete protein.
JD488205 - Sequence 469229 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1YRJ4, B2RNE4, B4DJ52, B9EGW3, ENST00000341871.1, ENST00000341871.2, ENST00000341871.3, ENST00000341871.4, ENST00000341871.5, ENST00000341871.6, ENST00000341871.7, NM_001004313, Q6QAJ8, TM220_HUMAN, uc002gmx.1, uc002gmx.2, uc002gmx.3, uc002gmx.4, uc002gmx.5
UCSC ID: ENST00000341871.8
RefSeq Accession: NM_001004313
Protein: Q6QAJ8 (aka TM220_HUMAN)
CCDS: CCDS32567.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.