Human Gene TEFM (ENST00000580840.1) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt J3KTG7)
Gencode Transcript: ENST00000580840.1
Gencode Gene: ENSG00000172171.11
Transcript (Including UTRs)
   Position: hg38 chr17:30,898,986-30,906,235 Size: 7,250 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr17:30,900,377-30,906,198 Size: 5,822 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:30,898,986-30,906,235)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: J3KTG7_HUMAN
DESCRIPTION: SubName: Full=Transcription elongation factor, mitochondrial;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.09 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 143.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.1037-0.030 Picture PostScript Text
3' UTR -315.501391-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023097 - Tex_RuvX-like_dom

ModBase Predicted Comparative 3D Structure on J3KTG7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  AJ314645 - Homo sapiens mRNA for hypothetical protein and STS SHGC-2390.
AF086465 - Homo sapiens full length insert cDNA clone ZD86E06.
BC064631 - Homo sapiens chromosome 17 open reading frame 42, mRNA (cDNA clone IMAGE:5739804), with apparent retained intron.
BC073169 - Homo sapiens chromosome 17 open reading frame 42, mRNA (cDNA clone IMAGE:6192569), complete cds.
AK026382 - Homo sapiens cDNA: FLJ22729 fis, clone HSI15685.
AK225474 - Homo sapiens mRNA for hypothetical protein LOC79736 variant, clone: HSI15685.
BC009025 - Homo sapiens chromosome 17 open reading frame 42, mRNA (cDNA clone IMAGE:4184795), partial cds.
CR457360 - Homo sapiens full open reading frame cDNA clone RZPDo834C1010D for gene FLJ22729, hypothetical protein FLJ22729; complete cds, incl. stopcodon.
BC024328 - Homo sapiens chromosome 17 open reading frame 42, mRNA (cDNA clone IMAGE:4253473).
CU692922 - Synthetic construct Homo sapiens gateway clone IMAGE:100023015 5' read C17orf42 mRNA.
KJ903213 - Synthetic construct Homo sapiens clone ccsbBroadEn_12607 TEFM gene, encodes complete protein.
AK298495 - Homo sapiens cDNA FLJ60776 complete cds.
JD411158 - Sequence 392182 from Patent EP1572962.
JD126149 - Sequence 107173 from Patent EP1572962.
JD449111 - Sequence 430135 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC024328, J3KTG7, J3KTG7_HUMAN, uc002hfw.1, uc002hfw.2, uc002hfw.3
UCSC ID: ENST00000580840.1
RefSeq Accession: NM_024683
Protein: J3KTG7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.