Human Gene ZPBP2 (ENST00000377940.3) from GENCODE V44
  Description: Homo sapiens zona pellucida binding protein 2 (ZPBP2), transcript variant 1, mRNA. (from RefSeq NM_198844)
Gencode Transcript: ENST00000377940.3
Gencode Gene: ENSG00000186075.13
Transcript (Including UTRs)
   Position: hg38 chr17:39,868,216-39,877,896 Size: 9,681 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr17:39,868,355-39,876,809 Size: 8,455 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:39,868,216-39,877,896)mRNA (may differ from genome)Protein (316 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZPBP2_HUMAN
DESCRIPTION: RecName: Full=Zona pellucida-binding protein 2; AltName: Full=ZPBP-like protein; Flags: Precursor;
FUNCTION: May be implicated in gamete interaction during fertilization.
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the zona pellucida-binding protein Sp38 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.04 RPKM in Testis
Total median expression: 71.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.90139-0.460 Picture PostScript Text
3' UTR -220.271087-0.203 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR010857 - Sp38-bd

Pfam Domains:
PF07354 - Zona-pellucida-binding protein (Sp38)

ModBase Predicted Comparative 3D Structure on Q6X784
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001675 acrosome assembly
GO:0007339 binding of sperm to zona pellucida

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0002199 zona pellucida receptor complex
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0031410 cytoplasmic vesicle
GO:0044297 cell body


-  Descriptions from all associated GenBank mRNAs
  AK292383 - Homo sapiens cDNA FLJ75797 complete cds, highly similar to Homo sapiens zona pellucida binding protein 2 (ZPBP2), transcript variant 2, mRNA.
BC043152 - Homo sapiens zona pellucida binding protein 2, mRNA (cDNA clone MGC:41930 IMAGE:5297840), complete cds.
AY251603 - Homo sapiens zona pellucida binding protein 2 (ZPBP2) mRNA, complete cds.
AY251604 - Homo sapiens zona pellucida binding protein 2 (ZPBP2) mRNA, complete cds; alternative transcript.
JD344476 - Sequence 325500 from Patent EP1572962.
KJ900822 - Synthetic construct Homo sapiens clone ccsbBroadEn_10216 ZPBP2 gene, encodes complete protein.
DQ573438 - Homo sapiens piRNA piR-41550, complete sequence.
JD170897 - Sequence 151921 from Patent EP1572962.
JD284792 - Sequence 265816 from Patent EP1572962.
JD516169 - Sequence 497193 from Patent EP1572962.
JD508986 - Sequence 490010 from Patent EP1572962.
JD299474 - Sequence 280498 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8L8, ENST00000377940.1, ENST00000377940.2, NM_198844, Q6X783, Q6X784, Q86XL5, uc002htf.1, uc002htf.2, uc002htf.3, uc002htf.4, ZPBP2_HUMAN, ZPBPL
UCSC ID: ENST00000377940.3
RefSeq Accession: NM_198844
Protein: Q6X784 (aka ZPBP2_HUMAN or ZPB2_HUMAN)
CCDS: CCDS11353.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.