Human Gene SNX11 (ENST00000359238.7) from GENCODE V44
  Description: Homo sapiens sorting nexin 11 (SNX11), transcript variant 2, mRNA. (from RefSeq NM_013323)
RefSeq Summary (NM_013323): This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000359238.7
Gencode Gene: ENSG00000002919.15
Transcript (Including UTRs)
   Position: hg38 chr17:48,107,766-48,123,601 Size: 15,836 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr17:48,112,044-48,121,508 Size: 9,465 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:48,107,766-48,123,601)mRNA (may differ from genome)Protein (270 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SNX11_HUMAN
DESCRIPTION: RecName: Full=Sorting nexin-11;
FUNCTION: May be involved in several stages of intracellular trafficking (By similarity).
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein; Cytoplasmic side (Potential).
DOMAIN: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
SIMILARITY: Belongs to the sorting nexin family.
SIMILARITY: Contains 1 PX (phox homology) domain.
SEQUENCE CAUTION: Sequence=AAD27834.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.81 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 396.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.2086-0.328 Picture PostScript Text
3' UTR -776.602093-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001683 - Phox

Pfam Domains:
PF00787 - PX domain

ModBase Predicted Comparative 3D Structure on Q9Y5W9
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0035091 phosphatidylinositol binding
GO:1901981 phosphatidylinositol phosphate binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016050 vesicle organization

Cellular Component:
GO:0005768 endosome
GO:0016020 membrane
GO:0019898 extrinsic component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK316374 - Homo sapiens cDNA, FLJ79273 complete cds, highly similar to Sorting nexin-11.
AK296095 - Homo sapiens cDNA FLJ51481 complete cds, highly similar to Sorting nexin-11.
AK091852 - Homo sapiens cDNA FLJ34533 fis, clone HLUNG2008247, highly similar to Sorting nexin-11.
AK023932 - Homo sapiens cDNA FLJ13870 fis, clone THYRO1001313, highly similar to Homo sapiens sorting nexin 11 (SNX11) mRNA.
AK296569 - Homo sapiens cDNA FLJ57149 complete cds, highly similar to Sorting nexin-11.
AF121861 - Homo sapiens sorting nexin 11 (SNX11) mRNA, complete cds.
JD137853 - Sequence 118877 from Patent EP1572962.
BC103721 - Homo sapiens sorting nexin 11, mRNA (cDNA clone MGC:111019 IMAGE:6162638), complete cds.
JD526845 - Sequence 507869 from Patent EP1572962.
AK298551 - Homo sapiens cDNA FLJ54273 complete cds, highly similar to Sorting nexin-11.
BC000768 - Homo sapiens sorting nexin 11, mRNA (cDNA clone MGC:2818 IMAGE:2963905), complete cds.
KJ893709 - Synthetic construct Homo sapiens clone ccsbBroadEn_03103 SNX11 gene, encodes complete protein.
CU674392 - Synthetic construct Homo sapiens gateway clone IMAGE:100018068 5' read SNX11 mRNA.
BT006723 - Homo sapiens sorting nexin 11 mRNA, complete cds.
DQ596698 - Homo sapiens piRNA piR-34764, complete sequence.
JD333371 - Sequence 314395 from Patent EP1572962.
JD174916 - Sequence 155940 from Patent EP1572962.
JD486797 - Sequence 467821 from Patent EP1572962.
JD111842 - Sequence 92866 from Patent EP1572962.
JD401877 - Sequence 382901 from Patent EP1572962.
JD118495 - Sequence 99519 from Patent EP1572962.
JD052308 - Sequence 33332 from Patent EP1572962.
JD501748 - Sequence 482772 from Patent EP1572962.
JD300820 - Sequence 281844 from Patent EP1572962.
JD427218 - Sequence 408242 from Patent EP1572962.
JD148445 - Sequence 129469 from Patent EP1572962.
JD334640 - Sequence 315664 from Patent EP1572962.
JD190115 - Sequence 171139 from Patent EP1572962.
JD382617 - Sequence 363641 from Patent EP1572962.
JD480642 - Sequence 461666 from Patent EP1572962.
JD404791 - Sequence 385815 from Patent EP1572962.
JD298806 - Sequence 279830 from Patent EP1572962.
JD432707 - Sequence 413731 from Patent EP1572962.
JD565821 - Sequence 546845 from Patent EP1572962.
JD392821 - Sequence 373845 from Patent EP1572962.
LF209291 - JP 2014500723-A/16794: Polycomb-Associated Non-Coding RNAs.
MA444868 - JP 2018138019-A/16794: Polycomb-Associated Non-Coding RNAs.
JD259587 - Sequence 240611 from Patent EP1572962.
JD522957 - Sequence 503981 from Patent EP1572962.
LF327478 - JP 2014500723-A/134981: Polycomb-Associated Non-Coding RNAs.
MA563055 - JP 2018138019-A/134981: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KRL6, D3DTV0, ENST00000359238.1, ENST00000359238.2, ENST00000359238.3, ENST00000359238.4, ENST00000359238.5, ENST00000359238.6, NM_013323, Q53YC0, Q9H885, Q9Y5W9, SNX11_HUMAN, uc002ing.1, uc002ing.2, uc002ing.3
UCSC ID: ENST00000359238.7
RefSeq Accession: NM_013323
Protein: Q9Y5W9 (aka SNX11_HUMAN or SNXB_HUMAN)
CCDS: CCDS11526.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.