Human Gene HOXB7 (ENST00000239165.9) from GENCODE V44
Description: Homo sapiens homeobox B7 (HOXB7), mRNA. (from RefSeq NM_004502) RefSeq Summary (NM_004502): This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000239165.9 Gencode Gene: ENSG00000260027.5 Transcript (Including UTRs) Position: hg38 chr17:48,607,232-48,611,017 Size: 3,786 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr17:48,607,842-48,610,918 Size: 3,077 Coding Exon Count: 2
ID:HXB7_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-B7; AltName: Full=Homeobox protein HHO.C1; AltName: Full=Homeobox protein Hox-2C; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. INTERACTION: P78527:PRKDC; NbExp=2; IntAct=EBI-1248457, EBI-352053; P13010:XRCC5; NbExp=9; IntAct=EBI-1248457, EBI-357997; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Antp homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09629
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0009952 anterior/posterior pattern specification GO:0030099 myeloid cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048704 embryonic skeletal system morphogenesis GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
US Server
