Human Gene ABCC3 (ENST00000427699.5) from GENCODE V44
Description: Homo sapiens ATP binding cassette subfamily C member 3 (ABCC3), transcript variant 2, mRNA. (from RefSeq NM_001144070) RefSeq Summary (NM_001144070): The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000427699.5 Gencode Gene: ENSG00000108846.16 Transcript (Including UTRs) Position: hg38 chr17:50,634,857-50,667,923 Size: 33,067 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr17:50,634,937-50,667,841 Size: 32,905 Coding Exon Count: 12
ID:MRP3_HUMAN DESCRIPTION: RecName: Full=Canalicular multispecific organic anion transporter 2; AltName: Full=ATP-binding cassette sub-family C member 3; AltName: Full=Multi-specific organic anion transporter D; Short=MOAT-D; AltName: Full=Multidrug resistance-associated protein 3; FUNCTION: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. SIMILARITY: Contains 2 ABC transmembrane type-1 domains. SIMILARITY: Contains 2 ABC transporter domains. SEQUENCE CAUTION: Sequence=AAB71756.1; Type=Frameshift; Positions=1334, 1338; Sequence=AAD01430.1; Type=Frameshift; Positions=355, 359, 361; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS; WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15438";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15438
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0008514 organic anion transmembrane transporter activity GO:0008559 xenobiotic-transporting ATPase activity GO:0015432 bile acid-exporting ATPase activity GO:0016887 ATPase activity GO:0022857 transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043225 ATPase-coupled anion transmembrane transporter activity
Biological Process: GO:0006855 drug transmembrane transport GO:0015721 bile acid and bile salt transport GO:0015722 canalicular bile acid transport GO:0042908 xenobiotic transport GO:0055085 transmembrane transport GO:0099133 ATP hydrolysis coupled anion transmembrane transport
US Server
