Human Gene HLF (ENST00000575345.5) from GENCODE V44
Description: Binds DNA specifically as homodimer or heterodimer with other PAR factors. (from UniProt Q16534) RefSeq Summary (NM_001330375): This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000575345.5 Gencode Gene: ENSG00000108924.14 Transcript (Including UTRs) Position: hg38 chr17:55,267,591-55,323,535 Size: 55,945 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr17:55,267,891-55,320,879 Size: 52,989 Coding Exon Count: 3
ID:HLF_HUMAN DESCRIPTION: RecName: Full=Hepatic leukemia factor; SUBUNIT: Binds DNA specifically as homodimer or heterodimer with other PAR factors. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highly expressed in liver; lower levels in lung and kidney. INDUCTION: Accumulates according to a robust circadian rhythm (By similarity). DISEASE: Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3. SIMILARITY: Belongs to the bZIP family. PAR subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=AAA58445.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HLFID47.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07716 - Basic region leucine zipper
ModBase Predicted Comparative 3D Structure on Q16534
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0035914 skeletal muscle cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048511 rhythmic process
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