ID:RHG28_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 28; AltName: Full=Rho-type GTPase-activating protein 28; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). TISSUE SPECIFICITY: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Contains 1 Rho-GAP domain. SEQUENCE CAUTION: Sequence=BAA91533.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA92552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2N2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051497 negative regulation of stress fiber assembly GO:1904425 negative regulation of GTP binding
US Server
