Human Gene CNN2 (ENST00000263097.9) from GENCODE V44
Description: Homo sapiens calponin 2 (CNN2), transcript variant 1, mRNA. (from RefSeq NM_004368) RefSeq Summary (NM_004368): The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000263097.9 Gencode Gene: ENSG00000064666.15 Transcript (Including UTRs) Position: hg38 chr19:1,026,608-1,039,065 Size: 12,458 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr19:1,026,662-1,037,900 Size: 11,239 Coding Exon Count: 7
ID:CNN2_HUMAN DESCRIPTION: RecName: Full=Calponin-2; AltName: Full=Calponin H2, smooth muscle; AltName: Full=Neutral calponin; FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. TISSUE SPECIFICITY: Heart and smooth muscle. SIMILARITY: Belongs to the calponin family. SIMILARITY: Contains 3 calponin-like repeats. SIMILARITY: Contains 1 CH (calponin-homology) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99439
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
