Human Gene HSD11B1L (ENST00000581893.5) from GENCODE V44
  Description: Homo sapiens hydroxysteroid 11-beta dehydrogenase 1 like (HSD11B1L), transcript variant d, mRNA. (from RefSeq NM_198708)
RefSeq Summary (NM_001267869): This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012].
Gencode Transcript: ENST00000581893.5
Gencode Gene: ENSG00000167733.14
Transcript (Including UTRs)
   Position: hg38 chr19:5,681,009-5,688,522 Size: 7,514 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr19:5,686,986-5,687,945 Size: 960 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:5,681,009-5,688,522)mRNA (may differ from genome)Protein (152 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DHI1L_HUMAN
DESCRIPTION: RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein; EC=1.1.1.-; AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3; Short=11-DH3; Short=11-beta-HSD3; AltName: Full=Short-chain dehydrogenase/reductase 10; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.91 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 405.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -260.90504-0.518 Picture PostScript Text
3' UTR -210.30577-0.364 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

Pfam Domains:
PF00106 - short chain dehydrogenase

ModBase Predicted Comparative 3D Structure on Q7Z5J1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity

Biological Process:
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC094798 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA (cDNA clone IMAGE:4801167).
AY268351 - Homo sapiens short-chain dehydrogenase/reductase 10a (SCDR10) mRNA, complete cds; alternatively spliced.
AY313895 - Homo sapiens short-chain dehydrogenase/reductase 10f (SCDR10) mRNA, complete cds; alternatively spliced.
AY313896 - Homo sapiens short-chain dehydrogenase/reductase 10g (SCDR10) mRNA, complete cds; alternatively spliced.
AK308206 - Homo sapiens cDNA, FLJ98154.
AY313894 - Homo sapiens short-chain dehydrogenase/reductase 10e (SCDR10) mRNA, complete cds; alternatively spliced.
AY268353 - Homo sapiens short-chain dehydrogenase/reductase 10c (SCDR10) mRNA, complete cds; alternatively spliced.
BC062777 - Homo sapiens cDNA clone IMAGE:4618237, partial cds.
AY268352 - Homo sapiens short-chain dehydrogenase/reductase 10b (SCDR10) mRNA, complete cds; alternatively spliced.
AY268354 - Homo sapiens short-chain dehydrogenase/reductase 10d (SCDR10) mRNA, complete cds; alternatively spliced.
BC053546 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA (cDNA clone IMAGE:5732320), complete cds.
BC072434 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA (cDNA clone IMAGE:5729121), complete cds.
BC018336 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA (cDNA clone IMAGE:3863398), complete cds.
BC152753 - Synthetic construct Homo sapiens clone IMAGE:100015977, MGC:184149 hydroxysteroid (11-beta) dehydrogenase 1-like (HSD11B1L) mRNA, encodes complete protein.
AB528801 - Synthetic construct DNA, clone: pF1KE0267, Homo sapiens HSD11B1L gene for hydroxysteroid (11-beta) dehydrogenase 1-like protein, without stop codon, in Flexi system.
BC093950 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA (cDNA clone IMAGE:7939795), partial cds.
BC112187 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA (cDNA clone IMAGE:8327655), partial cds.
CU690982 - Synthetic construct Homo sapiens gateway clone IMAGE:100023204 5' read HSD11B1L mRNA.
KJ896145 - Synthetic construct Homo sapiens clone ccsbBroadEn_05539 HSD11B1L gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: DHI1L_HUMAN, ENST00000581893.1, ENST00000581893.2, ENST00000581893.3, ENST00000581893.4, HSD3, NM_198708, Q05D45, Q52LF4, Q7Z5I9, Q7Z5J0, Q7Z5J1, Q7Z5P5, Q7Z5P6, Q7Z5P7, Q7Z5P8, SCDR10, uc002mcu.1, uc002mcu.2, uc002mcu.3, uc002mcu.4, uc002mcu.5
UCSC ID: ENST00000581893.5
RefSeq Accession: NM_001267869
Protein: Q7Z5J1 (aka DHI1L_HUMAN)
CCDS: CCDS58642.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.