Human Gene MRPL4 (ENST00000590669.5) from GENCODE V44
Description: Homo sapiens mitochondrial ribosomal protein L4 (MRPL4), transcript variant 3, mRNA. (from RefSeq NM_146388) RefSeq Summary (NM_146388): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000590669.5 Gencode Gene: ENSG00000105364.14 Transcript (Including UTRs) Position: hg38 chr19:10,252,010-10,259,125 Size: 7,116 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr19:10,252,254-10,258,738 Size: 6,485 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00573 - Ribosomal protein L4/L1 family
ModBase Predicted Comparative 3D Structure on Q9BYD3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF132962 - Homo sapiens CGI-28 protein mRNA, complete cds. JD446543 - Sequence 427567 from Patent EP1572962. BC000756 - Homo sapiens mitochondrial ribosomal protein L4, mRNA (cDNA clone MGC:2681 IMAGE:2819730), complete cds. BC009858 - Homo sapiens mitochondrial ribosomal protein L4, mRNA (cDNA clone MGC:16367 IMAGE:3928448), complete cds. AB049635 - Homo sapiens MRPL4 mRNA for mitochondrial ribosomal protein L4 (L4mt), complete cds. KJ904740 - Synthetic construct Homo sapiens clone ccsbBroadEn_14134 MRPL4-like gene, encodes complete protein. KJ893798 - Synthetic construct Homo sapiens clone ccsbBroadEn_03192 MRPL4 gene, encodes complete protein. AY007152 - Homo sapiens clone CDABP0091 mRNA sequence. JD106501 - Sequence 87525 from Patent EP1572962. JD042798 - Sequence 23822 from Patent EP1572962. JD182874 - Sequence 163898 from Patent EP1572962. JD089526 - Sequence 70550 from Patent EP1572962. JD112400 - Sequence 93424 from Patent EP1572962. JD222899 - Sequence 203923 from Patent EP1572962. JD222900 - Sequence 203924 from Patent EP1572962. JD475390 - Sequence 456414 from Patent EP1572962. JD453927 - Sequence 434951 from Patent EP1572962. JD144346 - Sequence 125370 from Patent EP1572962. JD534632 - Sequence 515656 from Patent EP1572962. JD136183 - Sequence 117207 from Patent EP1572962. JD387735 - Sequence 368759 from Patent EP1572962. JD197088 - Sequence 178112 from Patent EP1572962. JD532159 - Sequence 513183 from Patent EP1572962. JD119051 - Sequence 100075 from Patent EP1572962. JD201528 - Sequence 182552 from Patent EP1572962. JD431154 - Sequence 412178 from Patent EP1572962. JD291487 - Sequence 272511 from Patent EP1572962. JD444211 - Sequence 425235 from Patent EP1572962. JD337841 - Sequence 318865 from Patent EP1572962. JD463583 - Sequence 444607 from Patent EP1572962. JD045175 - Sequence 26199 from Patent EP1572962. JD088643 - Sequence 69667 from Patent EP1572962. JD267568 - Sequence 248592 from Patent EP1572962. JD448157 - Sequence 429181 from Patent EP1572962. JD351531 - Sequence 332555 from Patent EP1572962. JD522707 - Sequence 503731 from Patent EP1572962. JD139762 - Sequence 120786 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BYD3 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins