Human Gene BRME1 (ENST00000346736.6) from GENCODE V44
  Description: Homo sapiens chromosome 19 open reading frame 57 (C19orf57), transcript variant 3, mRNA. (from RefSeq NM_024323)
Gencode Transcript: ENST00000346736.6
Gencode Gene: ENSG00000132016.12
Transcript (Including UTRs)
   Position: hg38 chr19:13,882,355-13,906,165 Size: 23,811 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr19:13,882,802-13,904,892 Size: 22,091 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:13,882,355-13,906,165)mRNA (may differ from genome)Protein (637 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
LynxMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CS057_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C19orf57; AltName: Full=Pre-T/NK cell-associated protein 3B3;
INTERACTION: Q13155:AIMP2; NbExp=4; IntAct=EBI-741210, EBI-745226; Q9BT78:COPS4; NbExp=2; IntAct=EBI-741210, EBI-742413;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE CAUTION: Sequence=AAB02340.1; Type=Erroneous translation; Note=Wrong choice of frame;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.48 RPKM in Testis
Total median expression: 51.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.10128-0.407 Picture PostScript Text
3' UTR -170.90447-0.382 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q0VDD7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0007275 multicellular organism development

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  KJ904866 - Synthetic construct Homo sapiens clone ccsbBroadEn_14260 C19orf57-like gene, encodes complete protein.
KJ906311 - Synthetic construct Homo sapiens clone ccsbBroadEn_15981 C19orf57 gene, encodes complete protein.
KJ899529 - Synthetic construct Homo sapiens clone ccsbBroadEn_08923 C19orf57 gene, encodes complete protein.
AK097431 - Homo sapiens cDNA FLJ40112 fis, clone TESTI2008394.
BC119719 - Homo sapiens chromosome 19 open reading frame 57, mRNA (cDNA clone MGC:149720 IMAGE:40117748), complete cds.
L17327 - Human pre-T/NK cell associated protein (3B3) mRNA, 3' end.
BC012945 - Homo sapiens chromosome 19 open reading frame 57, mRNA (cDNA clone IMAGE:4708252), partial cds.
BC002891 - Homo sapiens chromosome 19 open reading frame 57, mRNA (cDNA clone IMAGE:3943685), partial cds.
JD511856 - Sequence 492880 from Patent EP1572962.
JD213612 - Sequence 194636 from Patent EP1572962.
JD270921 - Sequence 251945 from Patent EP1572962.
JD234874 - Sequence 215898 from Patent EP1572962.
JD400638 - Sequence 381662 from Patent EP1572962.
JD264358 - Sequence 245382 from Patent EP1572962.
JD176917 - Sequence 157941 from Patent EP1572962.
JD471877 - Sequence 452901 from Patent EP1572962.
JD289828 - Sequence 270852 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C19orf57, CS057_HUMAN, ENST00000346736.1, ENST00000346736.2, ENST00000346736.3, ENST00000346736.4, ENST00000346736.5, NM_024323, Q0VDD7, Q13411, Q8N825, Q96D63, Q9BU49, uc002mxl.1, uc002mxl.2
UCSC ID: ENST00000346736.6
RefSeq Accession: NM_001345844
Protein: Q0VDD7 (aka CS057_HUMAN)
CCDS: CCDS12299.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.