Human Gene HOMER3 (ENST00000433218.6) from GENCODE V44
Description: Homo sapiens homer scaffold protein 3 (HOMER3), transcript variant 3, mRNA. (from RefSeq NM_001145721) RefSeq Summary (NM_001145721): This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000433218.6 Gencode Gene: ENSG00000051128.19 Transcript (Including UTRs) Position: hg38 chr19:18,929,201-18,940,352 Size: 11,152 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr19:18,929,443-18,938,982 Size: 9,540 Coding Exon Count: 9
ID:HOME3_HUMAN DESCRIPTION: RecName: Full=Homer protein homolog 3; Short=Homer-3; FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. SUBUNIT: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. INTERACTION: P05067-8:APP; NbExp=3; IntAct=EBI-748420, EBI-302661; P26367:PAX6; NbExp=3; IntAct=EBI-748420, EBI-747278; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity). DOMAIN: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. SIMILARITY: Belongs to the Homer family. SIMILARITY: Contains 1 WH1 domain. SEQUENCE CAUTION: Sequence=AAB81545.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NSC5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0019904 protein domain specific binding GO:0035256 G-protein coupled glutamate receptor binding GO:0042802 identical protein binding
Biological Process: GO:0006605 protein targeting GO:0007216 G-protein coupled glutamate receptor signaling pathway GO:0032703 negative regulation of interleukin-2 production GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
US Server
