Human Gene TMEM161A (ENST00000162044.14) from GENCODE V49
  Description: transmembrane protein 161A, transcript variant 1 (from RefSeq NM_017814.3)
Gencode Transcript: ENST00000162044.14
Gencode Gene: ENSG00000064545.16
Transcript (Including UTRs)
   Position: hg38 chr19:19,119,169-19,138,478 Size: 19,310 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr19:19,119,930-19,138,428 Size: 18,499 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2025-09-17 13:57:07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:19,119,169-19,138,478)mRNA (may differ from genome)Protein (479 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T161A_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 161A; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM161 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.00 RPKM in Thyroid
Total median expression: 516.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.5050-0.310 Picture PostScript Text
3' UTR -305.40761-0.401 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019395 - Transmembrane_161A/B

Pfam Domains:
PF10268 - Predicted transmembrane protein 161AB

ModBase Predicted Comparative 3D Structure on Q9NX61
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0032526 response to retinoic acid
GO:0034599 cellular response to oxidative stress
GO:0034644 cellular response to UV
GO:0045739 positive regulation of DNA repair
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK096964 - Homo sapiens cDNA FLJ39645 fis, clone SMINT2004086.
BC005210 - Homo sapiens transmembrane protein 161A, mRNA (cDNA clone MGC:12224 IMAGE:4041226), complete cds.
AK225424 - Homo sapiens mRNA for hypothetical protein LOC54929 variant, clone: HRC09720.
AK000429 - Homo sapiens cDNA FLJ20422 fis, clone KAT02572.
LF384373 - JP 2014500723-A/191876: Polycomb-Associated Non-Coding RNAs.
MA619950 - JP 2018138019-A/191876: Polycomb-Associated Non-Coding RNAs.
AY358088 - Homo sapiens clone DNA57711 AVLG582 (UNQ582) mRNA, complete cds.
JD454994 - Sequence 436018 from Patent EP1572962.
JD291574 - Sequence 272598 from Patent EP1572962.
JD154026 - Sequence 135050 from Patent EP1572962.
JD139069 - Sequence 120093 from Patent EP1572962.
BC016478 - Homo sapiens transmembrane protein 161A, mRNA (cDNA clone IMAGE:3923800), partial cds.
JD370434 - Sequence 351458 from Patent EP1572962.
JD151181 - Sequence 132205 from Patent EP1572962.
JD422553 - Sequence 403577 from Patent EP1572962.
JD247981 - Sequence 229005 from Patent EP1572962.
JD298565 - Sequence 279589 from Patent EP1572962.
JD519990 - Sequence 501014 from Patent EP1572962.
LF372639 - JP 2014500723-A/180142: Polycomb-Associated Non-Coding RNAs.
MA608216 - JP 2018138019-A/180142: Polycomb-Associated Non-Coding RNAs.
JD216874 - Sequence 197898 from Patent EP1572962.
JD528242 - Sequence 509266 from Patent EP1572962.
JD103265 - Sequence 84289 from Patent EP1572962.
JD186155 - Sequence 167179 from Patent EP1572962.
JF432164 - Synthetic construct Homo sapiens clone IMAGE:100073313 transmembrane protein 161A (TMEM161A) gene, encodes complete protein.
KJ899037 - Synthetic construct Homo sapiens clone ccsbBroadEn_08431 TMEM161A gene, encodes complete protein.
LF372636 - JP 2014500723-A/180139: Polycomb-Associated Non-Coding RNAs.
MA608213 - JP 2018138019-A/180139: Polycomb-Associated Non-Coding RNAs.
LF372634 - JP 2014500723-A/180137: Polycomb-Associated Non-Coding RNAs.
MA608211 - JP 2018138019-A/180137: Polycomb-Associated Non-Coding RNAs.
LF372633 - JP 2014500723-A/180136: Polycomb-Associated Non-Coding RNAs.
MA608210 - JP 2018138019-A/180136: Polycomb-Associated Non-Coding RNAs.
CU675045 - Synthetic construct Homo sapiens gateway clone IMAGE:100019598 5' read TMEM161A mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KUE0, ENST00000162044.1, ENST00000162044.10, ENST00000162044.11, ENST00000162044.12, ENST00000162044.13, ENST00000162044.2, ENST00000162044.3, ENST00000162044.4, ENST00000162044.5, ENST00000162044.6, ENST00000162044.7, ENST00000162044.8, ENST00000162044.9, G5E9M6, NM_017814, Q7L2Y1, Q9NX61, T161A_HUMAN, uc002nlg.1, uc002nlg.2, uc002nlg.3, uc002nlg.4, uc002nlg.5, uc002nlg.6, UNQ582/PRO1152
UCSC ID: ENST00000162044.14
RefSeq Accession: NM_017814.3
Protein: Q9NX61 (aka T161A_HUMAN)
CCDS: CCDS12393.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.