Human Gene HPN (ENST00000392226.5) from GENCODE V44
Description: Homo sapiens hepsin (HPN), transcript variant 2, mRNA. (from RefSeq NM_002151) RefSeq Summary (NM_002151): This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Gencode Transcript: ENST00000392226.5 Gencode Gene: ENSG00000105707.15 Transcript (Including UTRs) Position: hg38 chr19:35,040,506-35,066,571 Size: 26,066 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr19:35,042,507-35,066,287 Size: 23,781 Coding Exon Count: 12
ID:HEPS_HUMAN DESCRIPTION: RecName: Full=Serine protease hepsin; EC=3.4.21.106; AltName: Full=Transmembrane protease serine 1; Contains: RecName: Full=Serine protease hepsin non-catalytic chain; Contains: RecName: Full=Serine protease hepsin catalytic chain; FUNCTION: Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. CATALYTIC ACTIVITY: Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Present in most tissues, with the highest level in liver. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 1 SRCR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05981
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.