Human Gene CYP2A7 (ENST00000291764.3) from GENCODE V44
Description: Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 2, mRNA. (from RefSeq NM_030589) RefSeq Summary (NM_030589): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000291764.3 Gencode Gene: ENSG00000198077.11 Transcript (Including UTRs) Position: hg38 chr19:40,875,439-40,882,752 Size: 7,314 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr19:40,875,693-40,882,210 Size: 6,518 Coding Exon Count: 8
ID:F8W816_HUMAN DESCRIPTION: SubName: Full=Cytochrome P450 2A7; SIMILARITY: Belongs to the cytochrome P450 family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F8W816
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0016491 oxidoreductase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0020037 heme binding GO:0046872 metal ion binding
Biological Process: GO:0055114 oxidation-reduction process
Descriptions from all associated GenBank mRNAs
U22029 - Human cytochrome P450 (CYP2A7) mRNA, complete cds. M33317 - Human cytochrome P450IIA4 (CYP2A4) mRNA, complete cds. JD207070 - Sequence 188094 from Patent EP1572962. JD138669 - Sequence 119693 from Patent EP1572962. JD163829 - Sequence 144853 from Patent EP1572962. JD045991 - Sequence 27015 from Patent EP1572962. JD045990 - Sequence 27014 from Patent EP1572962. JD435889 - Sequence 416913 from Patent EP1572962. BC117165 - Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 7, mRNA (cDNA clone MGC:150774 IMAGE:40125716), complete cds. BC143325 - Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 7, mRNA (cDNA clone MGC:176847 IMAGE:9051830), complete cds. JD216389 - Sequence 197413 from Patent EP1572962. JD374102 - Sequence 355126 from Patent EP1572962. JD460876 - Sequence 441900 from Patent EP1572962. HQ258268 - Synthetic construct Homo sapiens clone IMAGE:100072577 cytochrome P450, family 2, subfamily A, polypeptide 7 (CYP2A7), transcript variant 1 (CYP2A6) gene, encodes complete protein. KJ896678 - Synthetic construct Homo sapiens clone ccsbBroadEn_06072 CYP2A7 gene, encodes complete protein. JD189361 - Sequence 170385 from Patent EP1572962. JD054003 - Sequence 35027 from Patent EP1572962. JD351184 - Sequence 332208 from Patent EP1572962. JD486074 - Sequence 467098 from Patent EP1572962. JD393479 - Sequence 374503 from Patent EP1572962. JD462415 - Sequence 443439 from Patent EP1572962. JD332803 - Sequence 313827 from Patent EP1572962. JD494429 - Sequence 475453 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00232 - Caffeine metabolism hsa00830 - Retinol metabolism hsa00982 - Drug metabolism - cytochrome P450 hsa00983 - Drug metabolism - other enzymes hsa01100 - Metabolic pathways