Human Gene CYP2A7 (ENST00000291764.3) from GENCODE V44
  Description: Homo sapiens cytochrome P450 family 2 subfamily A member 7 (CYP2A7), transcript variant 2, mRNA. (from RefSeq NM_030589)
RefSeq Summary (NM_030589): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000291764.3
Gencode Gene: ENSG00000198077.11
Transcript (Including UTRs)
   Position: hg38 chr19:40,875,439-40,882,752 Size: 7,314 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr19:40,875,693-40,882,210 Size: 6,518 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:40,875,439-40,882,752)mRNA (may differ from genome)Protein (443 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
LynxMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F8W816_HUMAN
DESCRIPTION: SubName: Full=Cytochrome P450 2A7;
SIMILARITY: Belongs to the cytochrome P450 family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.96 RPKM in Liver
Total median expression: 18.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -129.60542-0.239 Picture PostScript Text
3' UTR -70.90254-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001128 - Cyt_P450
IPR017972 - Cyt_P450_CS
IPR002401 - Cyt_P450_E_grp-I

Pfam Domains:
PF00067 - Cytochrome P450

ModBase Predicted Comparative 3D Structure on F8W816
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

Biological Process:
GO:0055114 oxidation-reduction process


-  Descriptions from all associated GenBank mRNAs
  U22029 - Human cytochrome P450 (CYP2A7) mRNA, complete cds.
M33317 - Human cytochrome P450IIA4 (CYP2A4) mRNA, complete cds.
JD207070 - Sequence 188094 from Patent EP1572962.
JD138669 - Sequence 119693 from Patent EP1572962.
JD163829 - Sequence 144853 from Patent EP1572962.
JD045991 - Sequence 27015 from Patent EP1572962.
JD045990 - Sequence 27014 from Patent EP1572962.
JD435889 - Sequence 416913 from Patent EP1572962.
BC117165 - Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 7, mRNA (cDNA clone MGC:150774 IMAGE:40125716), complete cds.
BC143325 - Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 7, mRNA (cDNA clone MGC:176847 IMAGE:9051830), complete cds.
JD216389 - Sequence 197413 from Patent EP1572962.
JD374102 - Sequence 355126 from Patent EP1572962.
JD460876 - Sequence 441900 from Patent EP1572962.
HQ258268 - Synthetic construct Homo sapiens clone IMAGE:100072577 cytochrome P450, family 2, subfamily A, polypeptide 7 (CYP2A7), transcript variant 1 (CYP2A6) gene, encodes complete protein.
KJ896678 - Synthetic construct Homo sapiens clone ccsbBroadEn_06072 CYP2A7 gene, encodes complete protein.
JD189361 - Sequence 170385 from Patent EP1572962.
JD054003 - Sequence 35027 from Patent EP1572962.
JD351184 - Sequence 332208 from Patent EP1572962.
JD486074 - Sequence 467098 from Patent EP1572962.
JD393479 - Sequence 374503 from Patent EP1572962.
JD462415 - Sequence 443439 from Patent EP1572962.
JD332803 - Sequence 313827 from Patent EP1572962.
JD494429 - Sequence 475453 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00232 - Caffeine metabolism
hsa00830 - Retinol metabolism
hsa00982 - Drug metabolism - cytochrome P450
hsa00983 - Drug metabolism - other enzymes
hsa01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000291764.1, ENST00000291764.2, F8W816, F8W816_HUMAN, NM_030589, uc002opn.1, uc002opn.2, uc002opn.3
UCSC ID: ENST00000291764.3
RefSeq Accession: NM_030589
Protein: F8W816

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.