Human Gene HRC (ENST00000252825.9) from GENCODE V44
Description: Homo sapiens histidine rich calcium binding protein (HRC), mRNA. (from RefSeq NM_002152) RefSeq Summary (NM_002152): This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]. Gencode Transcript: ENST00000252825.9 Gencode Gene: ENSG00000130528.12 Transcript (Including UTRs) Position: hg38 chr19:49,151,198-49,155,396 Size: 4,199 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr19:49,151,296-49,155,237 Size: 3,942 Coding Exon Count: 6
ID:SRCH_HUMAN DESCRIPTION: RecName: Full=Sarcoplasmic reticulum histidine-rich calcium-binding protein; Flags: Precursor; FUNCTION: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen. SIMILARITY: To rabbit HRC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10529 - Histidine-rich Calcium-binding repeat region
ModBase Predicted Comparative 3D Structure on P23327
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002027 regulation of heart rate GO:0006936 muscle contraction GO:0008016 regulation of heart contraction GO:0010460 positive regulation of heart rate GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0033135 regulation of peptidyl-serine phosphorylation GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0045823 positive regulation of heart contraction GO:0051480 regulation of cytosolic calcium ion concentration GO:0051481 negative regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901899 positive regulation of relaxation of cardiac muscle GO:1903169 regulation of calcium ion transmembrane transport
Protein P23327 (Reactome details) participates in the following event(s):
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification
US Server
