Human Gene VRK3 (ENST00000594092.5) from GENCODE V44
Description: Homo sapiens VRK serine/threonine kinase 3 (VRK3), transcript variant 3, mRNA. (from RefSeq NM_001308420) RefSeq Summary (NM_001308420): This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000594092.5 Gencode Gene: ENSG00000105053.11 Transcript (Including UTRs) Position: hg38 chr19:49,981,700-50,025,327 Size: 43,628 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr19:49,982,167-50,016,162 Size: 33,996 Coding Exon Count: 11
ID:VRK3_HUMAN DESCRIPTION: RecName: Full=Inactive serine/threonine-protein kinase VRK3; AltName: Full=Serine/threonine-protein pseudokinase VRK3; AltName: Full=Vaccinia-related kinase 3; FUNCTION: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus (By similarity). SUBUNIT: Interacts with DUSP3 (By similarity). Interacts with RAN. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. SIMILARITY: Contains 1 protein kinase domain. CAUTION: Inactive as a kinase due to its inability to bind ATP (PubMed:19141289).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IV63
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
