Human Gene KCNC3 (ENST00000376959.6) from GENCODE V44
Description: Membrane; Multi-pass membrane protein (By similarity). (from UniProt E7ETH1) RefSeq Summary (NM_004977): The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]. Gencode Transcript: ENST00000376959.6 Gencode Gene: ENSG00000131398.15 Transcript (Including UTRs) Position: hg38 chr19:50,311,937-50,329,246 Size: 17,310 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr19:50,316,075-50,329,082 Size: 13,008 Coding Exon Count: 4
ID:E7ETH1_HUMAN DESCRIPTION: SubName: Full=Potassium voltage-gated channel subfamily C member 3; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF02214 - BTB/POZ domain PF11404 - Potassium voltage-gated channel
ModBase Predicted Comparative 3D Structure on E7ETH1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005267 potassium channel activity
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0051260 protein homooligomerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport
Cellular Component: GO:0008076 voltage-gated potassium channel complex GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
AK127492 - Homo sapiens cDNA FLJ45584 fis, clone BRTHA3013860. AB208930 - Homo sapiens mRNA for Shaw-related voltage-gated potassium channel protein 3 variant protein. DQ579801 - Homo sapiens piRNA piR-47913, complete sequence. AF055989 - Homo sapiens Shaw type potassium channel Kv3.3 (KCNC3) mRNA, complete cds. BC156302 - Synthetic construct Homo sapiens clone IMAGE:100061753, MGC:190091 potassium voltage-gated channel, Shaw-related subfamily, member 3 (KCNC3) mRNA, encodes complete protein. JD458287 - Sequence 439311 from Patent EP1572962. JD226480 - Sequence 207504 from Patent EP1572962. JD226481 - Sequence 207505 from Patent EP1572962. JD140286 - Sequence 121310 from Patent EP1572962. JD129703 - Sequence 110727 from Patent EP1572962.