Human Gene ZNF615 (ENST00000594083.5) from GENCODE V44
  Description: Homo sapiens zinc finger protein 615 (ZNF615), transcript variant 8, mRNA. (from RefSeq NM_001321322)
Gencode Transcript: ENST00000594083.5
Gencode Gene: ENSG00000197619.15
Transcript (Including UTRs)
   Position: hg38 chr19:51,991,334-52,008,196 Size: 16,863 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr19:51,992,880-52,003,711 Size: 10,832 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:51,991,334-52,008,196)mRNA (may differ from genome)Protein (742 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN615_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 615;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 19 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
SEQUENCE CAUTION: Sequence=BAC87399.1; Type=Miscellaneous discrepancy; Note=aberrant splicing;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.39 RPKM in Prostate
Total median expression: 127.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.60245-0.260 Picture PostScript Text
3' UTR -311.501546-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q8N8J6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  JD052293 - Sequence 33317 from Patent EP1572962.
AK094071 - Homo sapiens cDNA FLJ36752 fis, clone UTERU2017715, weakly similar to Homo sapiens zinc finger protein dp mRNA.
AX748441 - Sequence 1966 from Patent EP1308459.
AK091029 - Homo sapiens cDNA FLJ33710 fis, clone BRAWH2008058.
AX746740 - Sequence 265 from Patent EP1308459.
AK128361 - Homo sapiens cDNA FLJ46504 fis, clone THYMU3030072, moderately similar to Zinc finger protein 84.
BX647556 - Homo sapiens mRNA; cDNA DKFZp686N16128 (from clone DKFZp686N16128).
AK131494 - Homo sapiens cDNA FLJ16690 fis, clone TRACH3000134, moderately similar to ZINC FINGER PROTEIN 84.
BC053884 - Homo sapiens zinc finger protein 615, mRNA (cDNA clone IMAGE:6060422).
BX648594 - Homo sapiens mRNA; cDNA DKFZp686O05205 (from clone DKFZp686O05205).
CR936612 - Homo sapiens mRNA; cDNA DKFZp686O1554 (from clone DKFZp686O1554).
BC112961 - Homo sapiens cDNA clone IMAGE:7483635.
JD235347 - Sequence 216371 from Patent EP1572962.
JD261851 - Sequence 242875 from Patent EP1572962.
JD509977 - Sequence 491001 from Patent EP1572962.
JD303947 - Sequence 284971 from Patent EP1572962.
JD245158 - Sequence 226182 from Patent EP1572962.
JD561795 - Sequence 542819 from Patent EP1572962.
JD148621 - Sequence 129645 from Patent EP1572962.
AK096691 - Homo sapiens cDNA FLJ39372 fis, clone PEBLM2007832.
AK294977 - Homo sapiens cDNA FLJ61251 complete cds, highly similar to Homo sapiens zinc finger protein 615 (ZNF615), mRNA.
JD315026 - Sequence 296050 from Patent EP1572962.
JD280208 - Sequence 261232 from Patent EP1572962.
JD091095 - Sequence 72119 from Patent EP1572962.
JD288574 - Sequence 269598 from Patent EP1572962.
AK291734 - Homo sapiens cDNA FLJ76718 complete cds.
JD042664 - Sequence 23688 from Patent EP1572962.
JD225580 - Sequence 206604 from Patent EP1572962.
BC105100 - Homo sapiens zinc finger protein 615, mRNA (cDNA clone MGC:132760 IMAGE:8144103), complete cds.
BC105102 - Homo sapiens zinc finger protein 615, mRNA (cDNA clone MGC:132762 IMAGE:8144105), complete cds.
BC143429 - Homo sapiens zinc finger protein 615, mRNA (cDNA clone MGC:176954 IMAGE:9051937), complete cds.
KJ900568 - Synthetic construct Homo sapiens clone ccsbBroadEn_09962 ZNF615 gene, encodes complete protein.
DQ582196 - Homo sapiens piRNA piR-32308, complete sequence.
JD076385 - Sequence 57409 from Patent EP1572962.
JD440227 - Sequence 421251 from Patent EP1572962.
JD178427 - Sequence 159451 from Patent EP1572962.
JD515059 - Sequence 496083 from Patent EP1572962.
JD400704 - Sequence 381728 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N8J6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZKW9, ENST00000594083.1, ENST00000594083.2, ENST00000594083.3, ENST00000594083.4, NM_001321322, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3, Q8N8J6, uc002pyh.1, uc002pyh.2, uc002pyh.3, ZN615_HUMAN
UCSC ID: ENST00000594083.5
RefSeq Accession: NM_001321319
Protein: Q8N8J6 (aka ZN615_HUMAN)
CCDS: CCDS12846.1, CCDS59418.1, CCDS82387.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.