Human Gene RPL28 (ENST00000344063.7) from GENCODE V44
Description: Homo sapiens ribosomal protein L28 (RPL28), transcript variant 2, mRNA. (from RefSeq NM_000991) RefSeq Summary (NM_000991): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]. Gencode Transcript: ENST00000344063.7 Gencode Gene: ENSG00000108107.15 Transcript (Including UTRs) Position: hg38 chr19:55,385,932-55,392,085 Size: 6,154 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr19:55,386,358-55,388,332 Size: 1,975 Coding Exon Count: 4
ID:RL28_HUMAN DESCRIPTION: RecName: Full=60S ribosomal protein L28; INTERACTION: P43146:DCC; NbExp=3; IntAct=EBI-366357, EBI-1222919; SIMILARITY: Belongs to the ribosomal protein L28e family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P46779
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK096870 - Homo sapiens cDNA FLJ39551 fis, clone RECTM2000220, highly similar to 60S RIBOSOMAL PROTEIN L28. JD154423 - Sequence 135447 from Patent EP1572962. D28451 - Homo sapiens mRNA for ribosomal protein L28, 5'UTR region. AK311760 - Homo sapiens cDNA, FLJ92020, Homo sapiens ribosomal protein L28 (RPL28), mRNA. AK293736 - Homo sapiens cDNA FLJ57954 complete cds, highly similar to 60S ribosomal protein L28. BC010182 - Homo sapiens ribosomal protein L28, mRNA (cDNA clone MGC:20328 IMAGE:4301420), complete cds. U14969 - Human ribosomal protein L28 mRNA, complete cds. BC010173 - Homo sapiens ribosomal protein L28, mRNA (cDNA clone MGC:20081 IMAGE:4054251), complete cds. DQ893043 - Synthetic construct clone IMAGE:100005673; FLH192954.01X; RZPDo839B0278D ribosomal protein L28 (RPL28) gene, encodes complete protein. DQ896287 - Synthetic construct Homo sapiens clone IMAGE:100010747; FLH192950.01L; RZPDo839B0268D ribosomal protein L28 (RPL28) gene, encodes complete protein. BC011582 - Homo sapiens ribosomal protein L28, mRNA (cDNA clone MGC:20378 IMAGE:4561118), complete cds. AB209627 - Homo sapiens mRNA for ribosomal protein L28 variant protein. AB464159 - Synthetic construct DNA, clone: pF1KB6728, Homo sapiens RPL28 gene for ribosomal protein L28, without stop codon, in Flexi system. KJ892038 - Synthetic construct Homo sapiens clone ccsbBroadEn_01432 RPL28 gene, encodes complete protein. KJ897491 - Synthetic construct Homo sapiens clone ccsbBroadEn_06885 RPL28 gene, encodes complete protein. CR457024 - Homo sapiens full open reading frame cDNA clone RZPDo834C0115D for gene RPL28, ribosomal protein L28; complete cds, incl. stopcodon. DQ583324 - Homo sapiens piRNA piR-50436, complete sequence. AK125297 - Homo sapiens cDNA FLJ43307 fis, clone NT2NE2008060. AK025866 - Homo sapiens cDNA: FLJ22213 fis, clone HRC01527. JD513919 - Sequence 494943 from Patent EP1572962. HQ013233 - Homo sapiens clone pSWD3-2 minisatellite-associated sequence. BC015398 - Homo sapiens ribosomal protein L28, mRNA (cDNA clone IMAGE:3851516), with apparent retained intron.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03010 - Ribosome
Reactome (by CSHL, EBI, and GO)
Protein P46779 (Reactome details) participates in the following event(s):
R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-156827 L13a-mediated translation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72613 Eukaryotic Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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