Human Gene TMEM214 (ENST00000238788.14) from GENCODE V44
Description: Homo sapiens transmembrane protein 214 (TMEM214), transcript variant 1, mRNA. (from RefSeq NM_017727)
Gencode Transcript: ENST00000238788.14
Gencode Gene: ENSG00000119777.20
Transcript (Including UTRs)
Position: hg38 chr2:27,032,965-27,041,694 Size: 8,730 Total Exon Count: 17 Strand: +
Coding Region
Position: hg38 chr2:27,033,016-27,040,837 Size: 7,822 Coding Exon Count: 17
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TM214_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 214;
INTERACTION: O15116:LSM1; NbExp=1; IntAct=EBI-372318, EBI-347619;SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).SIMILARITY: Belongs to the TMEM214 family.SEQUENCE CAUTION: Sequence=AAL55739.1; Type=Erroneous initiation; Sequence=BAA91038.1; Type=Erroneous initiation; Sequence=BAC11331.1; Type=Frameshift; Positions=94; Sequence=CAH10591.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR019308 - DUF2359_TMEM214
Pfam Domains: PF10151 - TMEM214, C-terminal, caspase 4 activator
ModBase Predicted Comparative 3D Structure on Q6NUQ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC068479 - Homo sapiens transmembrane protein 214, mRNA (cDNA clone MGC:87131 IMAGE:4814193), complete cds.AK297150 - Homo sapiens cDNA FLJ57745 complete cds.AK296575 - Homo sapiens cDNA FLJ58194 complete cds.AK097308 - Homo sapiens cDNA FLJ39989 fis, clone STOMA2000678.AK074981 - Homo sapiens cDNA FLJ90500 fis, clone NT2RP3004025.CU686645 - Synthetic construct Homo sapiens gateway clone IMAGE:100022842 5' read FLJ20254 mRNA.KJ899031 - Synthetic construct Homo sapiens clone ccsbBroadEn_08425 TMEM214 gene, encodes complete protein.AL833725 - Homo sapiens mRNA; cDNA DKFZp666E065 (from clone DKFZp666E065).BC002467 - Homo sapiens transmembrane protein 214, mRNA (cDNA clone IMAGE:3347870), partial cds.JD372455 - Sequence 353479 from Patent EP1572962.JD169932 - Sequence 150956 from Patent EP1572962.JD390839 - Sequence 371863 from Patent EP1572962.JD134660 - Sequence 115684 from Patent EP1572962.JD190135 - Sequence 171159 from Patent EP1572962.JD500789 - Sequence 481813 from Patent EP1572962.AK315359 - Homo sapiens cDNA, FLJ96404.JD159150 - Sequence 140174 from Patent EP1572962.JD197451 - Sequence 178475 from Patent EP1572962.JD566806 - Sequence 547830 from Patent EP1572962.JD361175 - Sequence 342199 from Patent EP1572962.JD424746 - Sequence 405770 from Patent EP1572962.AK000261 - Homo sapiens cDNA FLJ20254 fis, clone COLF6926.AL834157 - Homo sapiens mRNA; cDNA DKFZp761L1314 (from clone DKFZp761L1314).AF289555 - Homo sapiens clone pp446 unknown mRNA.AK097001 - Homo sapiens cDNA FLJ39682 fis, clone SMINT2010200.JD555854 - Sequence 536878 from Patent EP1572962.JD536982 - Sequence 518006 from Patent EP1572962.JD181425 - Sequence 162449 from Patent EP1572962.JD251565 - Sequence 232589 from Patent EP1572962.JD470120 - Sequence 451144 from Patent EP1572962.JD209966 - Sequence 190990 from Patent EP1572962.JD370432 - Sequence 351456 from Patent EP1572962.JD276294 - Sequence 257318 from Patent EP1572962.JD123694 - Sequence 104718 from Patent EP1572962.JD195323 - Sequence 176347 from Patent EP1572962.JD165113 - Sequence 146137 from Patent EP1572962.JD382392 - Sequence 363416 from Patent EP1572962.JD165642 - Sequence 146666 from Patent EP1572962.JD165643 - Sequence 146667 from Patent EP1572962.JD543885 - Sequence 524909 from Patent EP1572962.JD305325 - Sequence 286349 from Patent EP1572962.JD335894 - Sequence 316918 from Patent EP1572962.JD280812 - Sequence 261836 from Patent EP1572962.JD288770 - Sequence 269794 from Patent EP1572962.JD165639 - Sequence 146663 from Patent EP1572962.JD201106 - Sequence 182130 from Patent EP1572962.JD164732 - Sequence 145756 from Patent EP1572962.JD103843 - Sequence 84867 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6NNF2, B3KUI9, B5MCD8, D6W547, ENST00000238788.1, ENST00000238788.10, ENST00000238788.11, ENST00000238788.12, ENST00000238788.13, ENST00000238788.2, ENST00000238788.3, ENST00000238788.4, ENST00000238788.5, ENST00000238788.6, ENST00000238788.7, ENST00000238788.8, ENST00000238788.9, NM_017727, PP446, Q53SW1, Q69YH4, Q6NUQ4, Q8NC45, Q8WZ37, Q9NXH2, TM214_HUMAN, uc002ria.1, uc002ria.2, uc002ria.3, uc002ria.4, uc002ria.5, uc002ria.6UCSC ID: ENST00000238788.14RefSeq Accession: NM_017727
Protein: Q6NUQ4
(aka TM214_HUMAN)
CCDS: CCDS42664.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.