ID:TF3C2_HUMAN DESCRIPTION: RecName: Full=General transcription factor 3C polypeptide 2; AltName: Full=TF3C-beta; AltName: Full=Transcription factor IIIC 110 kDa subunit; Short=TFIIIC 110 kDa subunit; Short=TFIIIC110; AltName: Full=Transcription factor IIIC subunit beta; FUNCTION: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 4 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WUA4
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006383 transcription from RNA polymerase III promoter GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter
AF054988 - Homo sapiens clone 23858 unknown mRNA, partial cds. BC020981 - Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa, mRNA (cDNA clone MGC:9704 IMAGE:3849379), complete cds. D13636 - Homo sapiens KIAA0011 mRNA, complete cds. JD503589 - Sequence 484613 from Patent EP1572962. JD250078 - Sequence 231102 from Patent EP1572962. JD357911 - Sequence 338935 from Patent EP1572962. JD240285 - Sequence 221309 from Patent EP1572962. JD495757 - Sequence 476781 from Patent EP1572962. JD504010 - Sequence 485034 from Patent EP1572962. JD195430 - Sequence 176454 from Patent EP1572962. BX647092 - Homo sapiens mRNA; cDNA DKFZp686K15171 (from clone DKFZp686K15171). JD465218 - Sequence 446242 from Patent EP1572962. JD154453 - Sequence 135477 from Patent EP1572962. AK307656 - Homo sapiens cDNA, FLJ97604. JD552131 - Sequence 533155 from Patent EP1572962. JD166480 - Sequence 147504 from Patent EP1572962. JD393043 - Sequence 374067 from Patent EP1572962. JD039237 - Sequence 20261 from Patent EP1572962. BT009799 - Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa mRNA, complete cds. AB463053 - Synthetic construct DNA, clone: pF1KA0011, Homo sapiens GTF3C2 gene for general transcription factor IIIC, polypeptide 2, beta 110kDa, without stop codon, in Flexi system. BC000212 - Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa, mRNA (cDNA clone MGC:1731 IMAGE:3508353), complete cds. KJ901473 - Synthetic construct Homo sapiens clone ccsbBroadEn_10867 GTF3C2 gene, encodes complete protein. CU674088 - Synthetic construct Homo sapiens gateway clone IMAGE:100017719 5' read GTF3C2 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8WUA4 (Reactome details) participates in the following event(s):
R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83788 Binding of TFIIIC to Type 2 promoter R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
