Human Gene YPEL5 (ENST00000261353.9) from GENCODE V44
  Description: Homo sapiens yippee like 5 (YPEL5), transcript variant 4, mRNA. (from RefSeq NM_016061)
Gencode Transcript: ENST00000261353.9
Gencode Gene: ENSG00000119801.13
Transcript (Including UTRs)
   Position: hg38 chr2:30,147,007-30,160,533 Size: 13,527 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr2:30,156,652-30,158,843 Size: 2,192 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:30,147,007-30,160,533)mRNA (may differ from genome)Protein (121 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: YPEL5_HUMAN
DESCRIPTION: RecName: Full=Protein yippee-like 5;
SIMILARITY: Belongs to the yippee family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D014635 Valproic Acid
  • C006780 bisphenol A
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D000393 Air Pollutants
  • D001564 Benzo(a)pyrene
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 56.06 RPKM in Testis
Total median expression: 1465.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.7080-0.371 Picture PostScript Text
3' UTR -391.401690-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002579 - Met_Sox_Rdtase_MsrB
IPR004910 - Yippee

Pfam Domains:
PF03226 - Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

ModBase Predicted Comparative 3D Structure on P62699
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005576 extracellular region
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen


-  Descriptions from all associated GenBank mRNAs
  AF151885 - Homo sapiens CGI-127 protein mRNA, complete cds.
AF172940 - Homo sapiens Yippee protein mRNA, partial cds.
AF135161 - Homo sapiens unknown mRNA.
JD139053 - Sequence 120077 from Patent EP1572962.
JD445968 - Sequence 426992 from Patent EP1572962.
AK307099 - Homo sapiens cDNA, FLJ97047.
AK311404 - Homo sapiens cDNA, FLJ18446.
AK025730 - Homo sapiens cDNA: FLJ22077 fis, clone HEP12728, highly similar to AF151885 Homo sapiens CGI-127 protein mRNA.
BC000836 - Homo sapiens yippee-like 5 (Drosophila), mRNA (cDNA clone MGC:4873 IMAGE:3456031), complete cds.
JD071552 - Sequence 52576 from Patent EP1572962.
BC047237 - Homo sapiens yippee-like 5 (Drosophila), mRNA (cDNA clone MGC:57416 IMAGE:5269563), complete cds.
AB098739 - Homo sapiens YPEL5 mRNA for yippee-like 5, complete cds.
DQ591527 - Homo sapiens piRNA piR-58639, complete sequence.
JD328668 - Sequence 309692 from Patent EP1572962.
JD021499 - Sequence 2523 from Patent EP1572962.
JD031936 - Sequence 12960 from Patent EP1572962.
JD086959 - Sequence 67983 from Patent EP1572962.
JD089706 - Sequence 70730 from Patent EP1572962.
JD306677 - Sequence 287701 from Patent EP1572962.
JD360841 - Sequence 341865 from Patent EP1572962.
JD273082 - Sequence 254106 from Patent EP1572962.
JD287933 - Sequence 268957 from Patent EP1572962.
JD514578 - Sequence 495602 from Patent EP1572962.
JD371713 - Sequence 352737 from Patent EP1572962.
JD261510 - Sequence 242534 from Patent EP1572962.
JD164728 - Sequence 145752 from Patent EP1572962.
JD290279 - Sequence 271303 from Patent EP1572962.
JD414002 - Sequence 395026 from Patent EP1572962.
JD048506 - Sequence 29530 from Patent EP1572962.
JD271376 - Sequence 252400 from Patent EP1572962.
JD224270 - Sequence 205294 from Patent EP1572962.
JD237647 - Sequence 218671 from Patent EP1572962.
JD147386 - Sequence 128410 from Patent EP1572962.
JD351406 - Sequence 332430 from Patent EP1572962.
JD298311 - Sequence 279335 from Patent EP1572962.
JD370932 - Sequence 351956 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P62699 (Reactome details) participates in the following event(s):

R-HSA-6798745 Exocytosis of tertiary granule lumen proteins
R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CGI-127, D6W568, ENST00000261353.1, ENST00000261353.2, ENST00000261353.3, ENST00000261353.4, ENST00000261353.5, ENST00000261353.6, ENST00000261353.7, ENST00000261353.8, NM_016061, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9, uc002rmz.1, uc002rmz.2, uc002rmz.3, uc002rmz.4, uc002rmz.5, uc002rmz.6, YPEL5_HUMAN
UCSC ID: ENST00000261353.9
RefSeq Accession: NM_016061
Protein: P62699 (aka YPEL5_HUMAN or YPL5_HUMAN)
CCDS: CCDS1771.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.