Human Gene ITPRIPL1 (ENST00000439118.3) from GENCODE V44
  Description: Homo sapiens ITPRIP like 1 (ITPRIPL1), transcript variant 2, mRNA. (from RefSeq NM_001008949)
Gencode Transcript: ENST00000439118.3
Gencode Gene: ENSG00000198885.10
Transcript (Including UTRs)
   Position: hg38 chr2:96,325,317-96,328,353 Size: 3,037 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr2:96,325,840-96,328,299 Size: 2,460 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:96,325,317-96,328,353)mRNA (may differ from genome)Protein (555 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IPIL1_HUMAN
DESCRIPTION: RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Belongs to the ITPRIP family.
CAUTION: It is uncertain whether Met-1 or Met-9 is the initiator.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.53 RPKM in Testis
Total median expression: 56.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -149.00342-0.436 Picture PostScript Text
3' UTR -5.0054-0.093 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026250 - INOS145TPRIP
IPR024808 - IP3R-int-like_1
IPR020950 - Mab-21-rel
IPR024810 - Mab-21_dom

Pfam Domains:
PF03281 - Mab-21 protein

ModBase Predicted Comparative 3D Structure on Q6GPH6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC073153 - Homo sapiens inositol 1,4,5-triphosphate receptor interacting protein-like 1, mRNA (cDNA clone MGC:90501 IMAGE:6018749), complete cds.
BC034503 - Homo sapiens inositol 1,4,5-triphosphate receptor interacting protein-like 1, mRNA (cDNA clone MGC:26971 IMAGE:4824775), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000439118.1, ENST00000439118.2, IPIL1_HUMAN, KIAA1754L, NM_001008949, Q6GPH6, Q8NE61, uc002svx.1, uc002svx.2, uc002svx.3, uc002svx.4, uc002svx.5
UCSC ID: ENST00000439118.3
RefSeq Accession: NM_001008949
Protein: Q6GPH6 (aka IPIL1_HUMAN)
CCDS: CCDS54378.1, CCDS33250.1, CCDS46360.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.