Human Gene SEPTIN10 (ENST00000397712.7) from GENCODE V44
Description: Homo sapiens septin 10 (SEPTIN10), transcript variant 1, mRNA. (from RefSeq NM_144710) RefSeq Summary (NM_144710): This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]. Gencode Transcript: ENST00000397712.7 Gencode Gene: ENSG00000186522.15 Transcript (Including UTRs) Position: hg38 chr2:109,542,799-109,613,966 Size: 71,168 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr2:109,544,309-109,613,827 Size: 69,519 Coding Exon Count: 11
ID:SEP10_HUMAN DESCRIPTION: RecName: Full=Septin-10; FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). SUBUNIT: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Using a GFP-fusion protein, detected in the nucleus (PubMed:12711328). TISSUE SPECIFICITY: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines. SIMILARITY: Belongs to the septin family. SEQUENCE CAUTION: Sequence=AAF67469.1; Type=Frameshift; Positions=444;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0V9
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
